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加那利群岛开展心脏移植自主项目的五年历程。

Five years of a self-sustaining heart transplant program in the Canary Islands.

作者信息

Groba-Marco Maria Del Val, Peña-Morant Vicente, González-Vílchez Francisco, Galván-Ruiz Mario, Fernandez-de-Sanmamed Miguel, Romero-Lujan Jose Luis, Portela-Torron Francisco, Caballero-Dorta Eduardo Jose, Pérez-Blanco Alicia, García-Quintana Antonio

机构信息

Cardiology Department, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Spain.

Departamento de Ciencias Medicas y Quirurgicas, Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.

出版信息

JHLT Open. 2025 May 13;9:100275. doi: 10.1016/j.jhlto.2025.100275. eCollection 2025 Aug.

DOI:10.1016/j.jhlto.2025.100275
PMID:40510599
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12162059/
Abstract

One significant challenge in heart transplant (HT) is the shortage of grafts and underutilization of the donor pool. This study analyzes the unique characteristics of the HT program in the Canary Islands, established in 2019, which operates with a predominantly self-sustaining donor pool. A retrospective review of the Spanish HT Registry and National Transplant Organization reports between 2020 and 2024 revealed that 97% of transplanted hearts originated from local donors. The geographical constraints of the islands create an unresolved issue with ischemic time, prompting the Canary region to establish a new HT program based on donation after circulatory death and extended criteria donors. These 2 initiatives have increased the donor pool and transplantation rates, while maintaining ethical allocation and comparable survival rates. This model highlights how regional programs can improve the underutilized donor pool and transplantation opportunities, offering a framework for future initiatives to optimize donation.

摘要

心脏移植(HT)面临的一个重大挑战是供体器官短缺以及供体库利用不足。本研究分析了2019年设立的加那利群岛心脏移植项目的独特特征,该项目主要依靠自给自足的供体库运作。对2020年至2024年西班牙心脏移植登记处和国家移植组织报告的回顾显示,97%的移植心脏来自当地供体。岛屿的地理限制导致缺血时间这一问题悬而未决,促使加那利地区基于循环死亡后捐赠和扩大标准供体建立了一个新的心脏移植项目。这两项举措增加了供体库和移植率,同时维持了伦理分配并保持了相当的生存率。该模式凸显了地区性项目如何改善未充分利用的供体库和移植机会,为未来优化捐赠的举措提供了一个框架。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ddf/12162059/bab95f10b172/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ddf/12162059/2c1751f79519/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ddf/12162059/bab95f10b172/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ddf/12162059/2c1751f79519/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ddf/12162059/bab95f10b172/gr2.jpg

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本文引用的文献

1
Successful heart transplant after 12 h preservation aboard a commercial flight.在商业航班上保存12小时后成功进行心脏移植。
Lancet. 2024 Mar 16;403(10431):1019. doi: 10.1016/S0140-6736(24)00258-7. Epub 2024 Feb 28.
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Cardiac Transplantation on the Canary Islands, A European Ultraperipheral Region: Organization, Optimized Utilization of Local Donors, and Early Transplant Outcomes.加那利群岛的心脏移植,欧洲一个超边缘地区:组织架构、当地供体的优化利用及早期移植结果
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Review of the allocation criteria for heart transplant in Spain in 2023. SEC-Heart Failure Association/ONT/SECCE consensus document.
2023 年西班牙心脏移植分配标准回顾。SECCE/ONT/西班牙心力衰竭协会共识文件。
Rev Esp Cardiol (Engl Ed). 2024 Jan;77(1):69-78. doi: 10.1016/j.rec.2023.11.001. Epub 2023 Nov 4.
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Hypothermic oxygenated perfusion (HOPE) safely and effectively extends acceptable donor heart preservation times: Results of the Australian and New Zealand trial.低温氧合灌注(HOPE)安全有效地延长了可接受的供心保存时间:澳大利亚和新西兰试验的结果。
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5
Ten Lessons From the Spanish Model of Organ Donation and Transplantation.西班牙器官捐献与移植模式的 10 点启示
Transpl Int. 2023 May 25;36:11009. doi: 10.3389/ti.2023.11009. eCollection 2023.
6
Heart Transplantation in a Distant Island Population: Accessibility and Outcomes in Patients From the Canary Islands Transplanted in Madrid.遥远岛屿人群中的心脏移植:加那利群岛患者在马德里接受心脏移植的可及性及治疗结果
Transplantation. 2020 Feb;104(2):223-226. doi: 10.1097/TP.0000000000002929.