Rawat Sarika, Vaishnav Neha, Dodiyar Yogesh, Dawer Ranjita A, Mandloi Roshan
Department of Obstetrics and Gynaecology, Dr. Laxmi Narayan Pandey Government Medical College, Ratlam, Madhya Pradesh, India.
Department of Anesthesiology, Dr. Laxmi Narayan Pandey Government Medical College, Ratlam, Madhya Pradesh, India.
J Pharm Bioallied Sci. 2025 May;17(Suppl 1):S745-S747. doi: 10.4103/jpbs.jpbs_1629_24. Epub 2025 Apr 17.
It is vital to assess methods of reducing the most severe labor pain. Paracetamol infusion is an efficient therapy available to eliminate labor pain in the active phase.
The present study aimed to assess the efficacy of intravenous infusion of 1000 mg paracetamol as an intrapartum labor analgesic.
In 220 nulliparous pregnant females undergoing vaginal delivery, after active labor phase onset, subjects were divided into two groups. Group I subjects were given 300cc normal saline and Group II subjects were given 300cc normal saline and 1 gram paracetamol. In two groups, Apgar scores, delivery type, duration of first and second labor stages, VAS scores, and maternal pain scores were assessed and compared.
Mean first- and second-stage labor length was significantly lower in Group I compared to Group II with = 0.001 and 0.037. Also, mean pain scores were significantly lower in paracetamol Group II compared to a control group with < 0.05.
Intravenous paracetamol prescription not only reduces labor pain in pregnant females but also decreases the duration of different labor stages, reduces the need for cesarean birth, and increases patient satisfaction with natural childbirth.
评估减轻最严重分娩疼痛的方法至关重要。对乙酰氨基酚静脉输注是一种有效的疗法，可消除活跃期的分娩疼痛。
本研究旨在评估静脉输注1000毫克对乙酰氨基酚作为产时分娩镇痛剂的疗效。
在220例接受阴道分娩的初产妇中，活跃期分娩开始后，将受试者分为两组。第一组受试者给予300毫升生理盐水，第二组受试者给予300毫升生理盐水和1克对乙酰氨基酚。在两组中，评估并比较阿氏评分、分娩方式、第一和第二产程持续时间、视觉模拟评分（VAS）以及产妇疼痛评分。
与第二组相比，第一组的第一和第二产程平均长度显著更低，P值分别为0.001和0.037。此外，与对照组相比，对乙酰氨基酚组（第二组）的平均疼痛评分显著更低，P<0.05。
静脉注射对乙酰氨基酚不仅能减轻孕妇的分娩疼痛，还能缩短不同产程的持续时间，减少剖宫产的需求，并提高患者对自然分娩的满意度。
