建立质子泵抑制剂（PPIs）与急性间质性肾炎（AIN）之间的关系。研究方案。
To Establish the Relationship between Proton Pump Inhibitors (PPIS) and Acute Interstitial Nephritis (AIN). Study Protocol.
作者信息
Bapurao Bite, Pathak Swanand, Ambad Ranjit Sidram
机构信息
Department of Pharmacology Jawaharlal Nehru Medical College, Wardha, Maharashtra, India.
Department of Biochemistry, Jawaharlal Nerhu Medical College, Datta Meghe Institute of Higher Education and Research Sawangi Meghe, Wardha, Maharashtra, India.
出版信息
J Pharm Bioallied Sci. 2025 May;17(Suppl 1):S916-S918. doi: 10.4103/jpbs.jpbs_1966_24. Epub 2025 Mar 6.
In India, utilization of PPI varies from 45 to 85%. PPIs were used in 82.96% of patients with chronic kidney disease. However, nowadays several case reports are suggesting PPI that induces AIN. The exact rate of this rare adverse event is difficult to estimate because many patients are taking multiple medications, which also make it difficult to establish a causal relation between AIN and PPI. Early detection of AIN and immediate discontinuation of the culprit drug may prevent the progress of AIN to the end stage of chronic kidney disease. So we planned a study to establish the relationship between PPI and AIN, if any.
在印度，质子泵抑制剂（PPI）的使用率在45%至85%之间。82.96%的慢性肾病患者使用了PPI。然而，如今有几例病例报告表明PPI会诱发急性间质性肾炎（AIN）。这种罕见不良事件的确切发生率难以估计，因为许多患者同时服用多种药物，这也使得难以确定AIN与PPI之间的因果关系。早期发现AIN并立即停用致病药物可能会防止AIN发展到慢性肾病终末期。因此，我们计划开展一项研究，以确定PPI与AIN之间是否存在关系。
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