肩周炎的基础科学研究：当前进展
Basic Science Research in Frozen Shoulder: Current Updates.
作者信息
Kim Jun-Young, Gahlot Nitesh, Park Hyung Bin
机构信息
Department of Orthopaedic Surgery, Daegu Catholic University School of Medicine, Daegu, Republic of Korea.
Department of Orthopedics, All India Institute of Medical Sciences-Jodhpur, Jodhpur, Rajasthan India.
出版信息
Indian J Orthop. 2024 Dec 2;59(6):774-784. doi: 10.1007/s43465-024-01294-1. eCollection 2025 Jun.
BACKGROUND
Frozen shoulder (FS) is a painful and functionally debilitating condition characterized by progressive shoulder stiffness. The etiology and pathomechanism of FS remain unclear but are likely influenced by genetic predisposition, systemic inflammation, and localized shoulder trauma.
METHODS
A comprehensive search was conducted on July 4, 2024, using PubMed, SCOPUS, and Google Scholar. Keywords included "frozen shoulder" and "adhesive capsulitis," with a focus on basic science-related topics.
RESULTS
Chronic inflammatory conditions in FS trigger a cascade involving cytokines, growth factors, increased extracellular matrix turnover, fibroblast activation, collagen deposition, and reduced matrix degradation, contributing to fibrosis and impaired joint mobility.
CONCLUSIONS
FS is a condition with multifactorial triggering factors that require targeted research to elucidate its mechanisms and identify molecular targets. Basic scientific studies are essential for developing biomarkers and advancing therapeutic strategies.
背景
肩周炎（FS）是一种以肩部进行性僵硬为特征的疼痛且功能致残的病症。肩周炎的病因和发病机制尚不清楚，但可能受遗传易感性、全身炎症和局部肩部创伤的影响。
方法
于2024年7月4日使用PubMed、SCOPUS和谷歌学术进行了全面检索。关键词包括“肩周炎”和“粘连性关节囊炎”，重点关注与基础科学相关的主题。
结果
肩周炎中的慢性炎症状态引发了一系列反应，涉及细胞因子、生长因子、细胞外基质周转增加、成纤维细胞活化、胶原蛋白沉积以及基质降解减少，导致纤维化和关节活动受限。
结论
肩周炎是一种具有多因素触发因素的病症，需要针对性研究以阐明其机制并确定分子靶点。基础科学研究对于开发生物标志物和推进治疗策略至关重要。
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