[具有抗有丝分裂特性的新型硫代嘧啶在细胞水平的作用模式]
[Mode of action at the cellular level of new thiopyrimidines with antimitotic properties].
作者信息
Bassleer R, De Paermentier F, Jamoulle J C, Lapière C L
出版信息
C R Acad Hebd Seances Acad Sci D. 1977 Mar 7;284(10):859-61.
PMID:405120
Abstract
New thiopyrimidine derivatives have been synthesized. Among them, several inhibit the multiplication of Chick embryo cells cultivated in vitro: they provoke strong nucleolar alterations, prevent the cells from entering into mitosis and can give rise to cell polyploidisation as to DNA.
摘要
新的硫代嘧啶衍生物已被合成。其中，有几种能抑制体外培养的鸡胚细胞的增殖：它们引起强烈的核仁变化，阻止细胞进入有丝分裂，并可导致细胞DNA多倍体化。
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