Benoit G, Feuilhade de Chauvin M, Cordonnier C, Astier A, Bernaudin J F
Am Rev Respir Dis. 1985 Oct;132(4):748-51. doi: 10.1164/arrd.1985.132.4.748.
Oxalic acid is a fermentation product of Aspergillus. We have measured the oxalic acid level in bronchoalveolar lavage fluids recovered from immunocompromised patients with and without invasive pulmonary aspergillosis. These levels were significantly higher in patients with invasive aspergillosis than in patients with pneumonitis of other causes. Thus, the determination of oxalic acid in bronchoalveolar lavage could be a presumptive argument for invasive aspergillosis until positive fungal cultures or histologic diagnosis; its potential value in monitoring the course of invasive pulmonary aspergillosis, particularly under treatment, has to be confirmed in more patients.
草酸是曲霉菌的发酵产物。我们检测了从患有和未患有侵袭性肺曲霉病的免疫功能低下患者中回收的支气管肺泡灌洗液中的草酸水平。侵袭性曲霉病患者的这些水平显著高于其他原因引起的肺炎患者。因此，在真菌培养结果呈阳性或进行组织学诊断之前，测定支气管肺泡灌洗液中的草酸可能是侵袭性曲霉病的一个推测性依据；其在监测侵袭性肺曲霉病病程，尤其是在治疗过程中的潜在价值，还需要在更多患者中得到证实。
