Malo J L, Gauthier R, Lemire I, Cartier A, Ghezzo H, Martin R R
Am Rev Respir Dis. 1985 Oct;132(4):848-52. doi: 10.1164/arrd.1985.132.4.848.
The time course of recovery from airway response induced by the inhalation of progressively doubling doses of histamine phosphate (3 to 4 depending on the subject) was studied in 8 asthmatic subjects by serial measurements of lung resistance (RL). For every subject, the time required for functional recovery became longer with increasing histamine doses and/or degrees of airway response. The slopes of the curves obtained from a single exponential fit relating time on the abscissa and functional recovery on the ordinate were significantly (F = 4.9 to 50.0, p less than 0.01) and progressively lower in 7 of 8 instances. This suggested a multiple compartment model, which was confirmed (r2 greater than or equal to 0.95) in 5 subjects by applying a double exponential regression that provided the most satisfactory fit. We conclude that the recovery from airway response caused by inhaled histamine is longer with increasing doses of histamine and/or degrees of airway response. A double-compartment model, a fast one followed by a slow one, fit this pattern of recovery in 5 of the 8 subjects.
通过连续测量肺阻力（RL），在8名哮喘患者中研究了吸入逐渐加倍剂量的磷酸组胺（根据受试者情况为3至4倍剂量）所诱发的气道反应的恢复时间进程。对于每一位受试者，随着组胺剂量增加和/或气道反应程度加重，功能恢复所需时间变长。在8个案例中的7个案例中，从横坐标为时间、纵坐标为功能恢复的单指数拟合得到的曲线斜率显著降低（F = 4.9至50.0，p小于0.01），且呈逐渐降低趋势。这提示了一个多室模型，通过应用能提供最满意拟合的双指数回归，在5名受试者中得到了证实（r2大于或等于0.95）。我们得出结论，随着组胺剂量增加和/或气道反应程度加重，吸入组胺所致气道反应的恢复时间变长。双室模型，即一个快速恢复阶段后接着一个缓慢恢复阶段，在8名受试者中的5名受试者中符合这种恢复模式。
