E-钙黏蛋白：细胞信号传导的引导者。
E-Cadherin: A conductor of cellular signaling.
作者信息
Kehrberg Rachel J, DeMali Kris A
机构信息
Roy J. and Lucille A. Carver College of Medicine at the University of Iowa, Department of Biochemistry and Molecular Biology, 51 Newton Rd, Iowa City, IA 52242, USA.
Roy J. and Lucille A. Carver College of Medicine at the University of Iowa, Department of Biochemistry and Molecular Biology, 51 Newton Rd, Iowa City, IA 52242, USA.
出版信息
Curr Opin Cell Biol. 2025 Aug;95:102559. doi: 10.1016/j.ceb.2025.102559. Epub 2025 Jun 12.
Abstract
Upon engagement of E-cadherin or when mechanical force is applied, E-cadherin recruits cytoskeletal proteins and triggers various signal transduction cascades including PI3K, Src, Rho family GTPases, kinases, YAP/TAZ, AMPK, and other metabolic enzymes. These cascades modulate E-cadherin's stability, viscosity, and its connection to the actin cytoskeleton, thereby reinforcing cell-cell adhesion.
摘要
当E-钙黏蛋白被激活或施加机械力时，E-钙黏蛋白招募细胞骨架蛋白并触发各种信号转导级联反应，包括PI3K、Src、Rho家族GTP酶、激酶、YAP/TAZ、AMPK和其他代谢酶。这些级联反应调节E-钙黏蛋白的稳定性、黏滞性及其与肌动蛋白细胞骨架的连接，从而加强细胞间黏附。
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