ABCF1的非规范和多样化功能洞察：从健康到疾病
Insights into Noncanonical and Diversified Functions of ABCF1: From Health to Disease.
作者信息
Duan Junyi, Saini Prince, Fong Yick W
机构信息
Brigham Regenerative Medicine Center, Brigham and Women's Hospital, Boston, MA, USA; Heart and Vascular Institute, Mass General Brigham, Harvard Medical School, Boston, MA, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA.
Brigham Regenerative Medicine Center, Brigham and Women's Hospital, Boston, MA, USA; Heart and Vascular Institute, Mass General Brigham, Harvard Medical School, Boston, MA, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA.
出版信息
J Mol Biol. 2025 Jun 11;437(17):169286. doi: 10.1016/j.jmb.2025.169286.
The ATP-binding cassette (ABC) family is one of the largest and most ancient classes of transporters found in nearly all living organisms. However, ABCF1 lacks a transmembrane domain and therefore does not function as a transporter. Recent studies point to an unexpectedly diverse role of ABCF1 in regulating cell-essential processes from mRNA translation, innate immune response, and phagocytosis in somatic cells, to transcriptional regulation in embryonic stem cells. ABCF1's functional plasticity is in part mediated by its disordered low-complexity domain (LCD) to enable dynamic biomolecular interactions. In this review, we discuss how ABCF1 takes advantage of the LCD to expand its functional repertoire and highlight fundamental principles of biomolecular assembly driving biological reactions. We also discuss the functions and mechanisms of ABCF1 in development and tissue homeostasis, and how dysregulation of ABCF1 contributes to diseases such as inflammatory disease and cancer.
ATP结合盒（ABC）家族是在几乎所有生物中发现的最大且最古老的转运蛋白类别之一。然而，ABCF1缺乏跨膜结构域，因此不具备转运蛋白的功能。最近的研究表明，ABCF1在调节细胞关键过程中发挥着意想不到的多样作用，这些过程包括从体细胞中的mRNA翻译、先天免疫反应和吞噬作用，到胚胎干细胞中的转录调控。ABCF1的功能可塑性部分是由其无序的低复杂性结构域（LCD）介导的，以实现动态的生物分子相互作用。在这篇综述中，我们讨论了ABCF1如何利用LCD来扩展其功能范围，并强调了驱动生物反应的生物分子组装的基本原理。我们还讨论了ABCF1在发育和组织稳态中的功能和机制，以及ABCF1的失调如何导致炎症性疾病和癌症等疾病。
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