Fleury P, Basset J M, Candau P, Bré M, Despreaux G, Fabre A, Saliba N
Ann Otolaryngol Chir Cervicofac. 1985;102(4):209-15.
The authors report 15 cases collected over a period of 13 years (1972 - 1984) of a particularly serious eventuality affecting certain evacuation cavities: Early recurrence of diffuse hypertrophic osteitis (E.R.D.H.O.). This is a rare complication, occurring in 1.5% of cases of chronic otitis. However, the fact of having operated upon 7 cases in 1984 alone, whilst during the previous 12 years, only 8 had been seen, raised the alarm. The classical pattern of this complication occurs in 3 stages, each involving surgical operation: at the outset, chronic otitis with cholesteatoma or osteitis, most often mixed, for which an "inadequate" surgical procedure is performed. then, after a variable period which may exceed 10 years, a very large evacuation cavity was created by the authors. finally, 3rd and final stage: within 6 months, this cavity filled progressively and, at operation, the authors discovered a cavity virtually completely filled with a "fantastic" "moist sugar" osteitis, requiring a new evacuation cavity, even larger than that created before. In all cases, a successful result was obtained within a varying period, sometimes accompanied by spectacular improvement in general condition. The most plausible etiopathogenic hypothesis advanced to attempt to explain this phenomenon is that of secondary infection by a varied microbial flora, including, on the one hand, aerobic organisms usually discovered in such cases (pseudomonas pyocyaneus, proteus mirabilis) and, secondly, this being of essential importance, "anaerobic" bacteria, the bacteriological diagnosis of which requires application of a strict protocol. The authors have taken three decisions following their bibliographic investigations.(ABSTRACT TRUNCATED AT 250 WORDS)
作者报告了在13年（1972 - 1984年）期间收集的15例发生在某些乳突根治术腔的特别严重的情况：弥漫性肥厚性骨炎早期复发（E.R.D.H.O.）。这是一种罕见的并发症，在慢性中耳炎病例中发生率为1.5%。然而，仅在1984年就有7例手术病例，而在之前的12年里仅发现8例，这敲响了警钟。这种并发症的典型模式分三个阶段出现，每个阶段都涉及外科手术：一开始是伴有胆脂瘤或骨炎的慢性中耳炎，大多为混合性，对此进行了“不充分”的外科手术。然后，经过一段可能超过10年的可变时间后，作者创建了一个非常大的术腔。最后，第三也是最后阶段：在6个月内，这个术腔逐渐被填满，手术时作者发现一个几乎完全被一种“奇异的”“湿糖样”骨炎填满的术腔，需要一个比之前创建的更大的新术腔。在所有病例中，在不同时期都取得了成功的结果，有时全身状况还会有显著改善。为试图解释这一现象而提出的最合理的病因假设是多种微生物菌群的继发感染，一方面包括这类病例中通常发现的需氧菌（铜绿假单胞菌、奇异变形杆菌），另一方面，这至关重要的是“厌氧菌”，其细菌学诊断需要应用严格的方案。作者在文献研究后做出了三项决定。（摘要截断于250字）
