Shit Manik, Mahapatra Manas, Halder Satyajit, Samanta Arnab, Anas Mahammad, Jana Kuladip, Sinha Chittaranjan
Department of Chemistry, Jadavpur University, Jadavpur, Kolkata 700032, India.
Centre for Education and Research on Macromolecules (CERM), CESAM Research Unit, Department of Chemistry, University of Liege, Quartier Agora, Sart-Tilman, B6A, Liege 4000, Belgium.
ACS Appl Bio Mater. 2025 Jul 21;8(7):6132-6144. doi: 10.1021/acsabm.5c00672. Epub 2025 Jun 13.
Zinc is the second most prevalent biometal found in the human body. Zn-based polymers have been gaining attention as anticancer drugs without interfering with the normal activites of cell lines. With this importance, we have synthesized Zn(II)-based 2D heterobridging coordination polymers, {[Zn(tdc)(bpms)(HO)], ()} and {[Zn(tdc)(bpds)(HO)·2HO], ()} (tdc, 2,5-thiophene dicarboxylate; bpms, 4,4'-dipyridyl sulfide; and bpds, 4,4'-dipyridyl disulfide). The structures demonstrate that tdc bridges through monodentate coordination of carboxylate-O and (O, O)-chelation to neighboring Zn(II) centers to constitute the coordination polymer; bpms/bpds act as pyridyl-N connecting ligands and propagate almost perpendicular to the previous chain and design the 2D CPs. The materials emit in the blue region with fluorescence lifetimes of 6.08 ns () and 5.41 ns (). The antiproliferative and apoptotic efficacies of the CPs have been studied in the presence of four cancer cell lines (human breast cancer cells (MCF-7), human prostate cancer cells (PC-3), lung carcinoma epithelial cells (A549), and triple-negative breast cancer cells (MDA-MB-231)) and have been compared with the standard anticancer drug, i.e., . The CPs are not cytotoxic to the human fetal lung fibroblast cell line (WI-38), and the highest anticancer efficiency is observed against MCF-7 (IC: 14.62 ± 1.49 () and 24.39 ± 1.23 μM () with reference to (IC, 6 μM). This study has a great deal of potential for the development of pharmaceuticals and provides an overview of the use of coordination polymers for medicinal purposes.
锌是人体中第二普遍存在的生物金属。锌基聚合物作为抗癌药物受到关注，且不会干扰细胞系的正常活动。鉴于此重要性，我们合成了基于Zn(II)的二维异桥联配位聚合物{[Zn(tdc)(bpms)(H₂O)]，( )}和{[Zn(tdc)(bpds)(H₂O)·2H₂O]，( )}（tdc为2,5-噻吩二甲酸；bpms为4,4'-二吡啶硫醚；bpds为4,4'-二吡啶二硫醚）。结构表明tdc通过羧酸根-O的单齿配位和(O,O)-螯合作用与相邻的Zn(II)中心桥连，构成配位聚合物；bpms/bpds作为吡啶基-N连接配体，几乎垂直于前一条链延伸，形成二维配位聚合物。这些材料在蓝色区域发射荧光，荧光寿命分别为6.08 ns( )和5.41 ns( )。在四种癌细胞系（人乳腺癌细胞(MCF-7)、人前列腺癌细胞(PC-3)、肺癌上皮细胞(A549)和三阴性乳腺癌细胞(MDA-MB-231)）存在的情况下，研究了配位聚合物的抗增殖和凋亡功效，并与标准抗癌药物即( )进行了比较。配位聚合物对人胎儿肺成纤维细胞系(WI-38)无细胞毒性，对MCF-7观察到最高的抗癌效率（相对于( )的IC₅₀为14.62 ± 1.49( )和24.39 ± 1.23 μM( )，( )的IC₅₀为6 μM）。这项研究在药物开发方面有很大潜力，并概述了配位聚合物在医学上的应用。
