Rahimi Mohammad Rahman, Symonds Michael E, Faraji Hassan, Golpasandi Hadi
Department of Exercise Physiology, University of Kurdistan, Sanandaj, Iran.
Academic Unit of Population and Lifespan Sciences, Centre for Perinatal Research, School of Medicine, University of Nottingham, Nottingham, UK.
Physiol Rep. 2025 Jun;13(12):e70392. doi: 10.14814/phy2.70392.
Asprosin, a protein that enhances insulin resistance by stimulating hepatic glucose secretion, is linked to obesity, metabolic disorders, and cardiovascular diseases. This systematic review and meta-analysis investigate the influence of exercise training (ET) on circulating concentrations of asprosin. A systematic search of PubMed, Web of Science, and Google Scholar databases was conducted for all randomized controlled clinical trials from January 2016 to November 2024. A total of 431 relevant articles were retrieved and screened according to the study population, intervention method, and study type, resulting in the selection of 14 articles for the meta-analysis. All statistical results were analyzed using Comprehensive Meta-Analysis Software version 2 (CMA2). The overall effect size, using Hedges' g, based on the random effects model for asprosin with ET, was -1.70 (95% CI -2.17 to -1.23, p = 0.0001). A decrease in asprosin concentration was observed with all types of ET including aerobic training (AT, H = -1.71, p = 0.0001), high-intensity interval training (HIIT, H = -1.81, p = 0.001), and resistance training (RT, H = -1.62, p = 0.0001). Furthermore, subgroup analysis showed differences in asprosin based on body mass index (Q-value = 11.09, df = 2, p = 0.004) and health status of the subjects (Q-value = 12.64, df = 2, p = 0.002); however, there were no differences based on sex (p = 0.67), types (p = 0.96), and duration (p = 0.34) of training. Our findings suggest that ET is associated with a decrease in circulating asprosin that could have a beneficial effect in preventing metabolic disease that is enhanced with obesity. Systematic review registration PROSPERO: CRD42023468813.
阿朴脂蛋白是一种通过刺激肝脏葡萄糖分泌来增强胰岛素抵抗的蛋白质，它与肥胖、代谢紊乱和心血管疾病有关。本系统评价和荟萃分析研究了运动训练（ET）对循环中阿朴脂蛋白浓度的影响。对2016年1月至2024年11月期间所有随机对照临床试验在PubMed、Web of Science和谷歌学术数据库中进行了系统检索。根据研究人群、干预方法和研究类型共检索到431篇相关文章并进行筛选，最终选择14篇文章进行荟萃分析。所有统计结果均使用综合荟萃分析软件2.0版（CMA2）进行分析。基于随机效应模型，运动训练对阿朴脂蛋白的总体效应量（使用Hedges' g）为-1.70（95%可信区间-2.17至-1.23，p = 0.0001）。在包括有氧训练（AT，H = -1.71，p = 0.0001）、高强度间歇训练（HIIT，H = -1.81，p = 0.001）和抗阻训练（RT，H = -1.62，p = 0.0001）在内的所有类型的运动训练中，均观察到阿朴脂蛋白浓度降低。此外，亚组分析显示，基于体重指数（Q值 = 11.09，自由度 = 2，p = 0.004）和受试者健康状况（Q值 = 12.64，自由度 = 2，p = 0.002），阿朴脂蛋白存在差异；然而，基于性别（p = 0.67）、训练类型（p = 0.96）和训练持续时间（p = 0.34）则无差异。我们的研究结果表明，运动训练与循环中阿朴脂蛋白的降低有关，这可能对预防因肥胖而加重的代谢性疾病具有有益作用。系统评价注册号：PROSPERO：CRD42023468813。
