Mahvi D M, Meyers W C, Bast R C, Seigler H F, Metzgar R S
Ann Surg. 1985 Oct;202(4):440-5. doi: 10.1097/00000658-198510000-00005.
DU-PAN-2 is a high molecular weight glycoprotein defined by a murine monoclonal antibody elicited to a pancreatic ductal adenocarcinoma cell line. This monoclonal antibody recognizes an oncofetal antigen present on the surface of pancreatic tumor cells. The antigen has also been detected in the sera of patients with adenocarcinoma of the pancreas by a competition radioimmunoassay (RIA). Ninety-four per cent (31/33) of patients with pancreatic adenocarcinoma in this study had DU-PAN-2 serum antigen levels greater than 300 units/ml by RIA, whereas sera from normal adults had serum levels less than 300 units/ml. Serial studies of DU-PAN-2 serum antigen in pancreatic cancer patients with elevated DU-PAN-2 serum levels (mean: 2873 units/ml) and surgically resectable neoplasms demonstrated a return to the normal range within 1 to 3 weeks after surgery in five of six patients. Five patients in clinical remission had normal DU-PAN-2 serum levels (mean: 110 units/ml). With tumor progression, however, the DU-PAN-2 level increased in all patients (mean: 2835 units/ml) an average of 2 months before evidence of progressive disease by clinical parameters. Serial DU-PAN-2 determinations are sensitive monitors of the progression of pancreatic cancer and may be useful as early indicators of response to therapy.
DU - PAN - 2是一种高分子量糖蛋白，由针对胰腺导管腺癌细胞系产生的鼠单克隆抗体所定义。这种单克隆抗体识别存在于胰腺肿瘤细胞表面的一种癌胚抗原。通过竞争放射免疫测定法（RIA），在胰腺癌患者的血清中也检测到了这种抗原。在本研究中，94%（31/33）的胰腺腺癌患者经RIA检测，其DU - PAN - 2血清抗原水平高于300单位/毫升，而正常成年人血清水平低于300单位/毫升。对DU - PAN - 2血清水平升高（平均：2873单位/毫升）且肿瘤可手术切除的胰腺癌患者进行的系列研究表明，六名患者中有五名在术后1至3周内血清水平恢复至正常范围。五名临床缓解患者的DU - PAN - 2血清水平正常（平均：110单位/毫升）。然而，随着肿瘤进展，所有患者的DU - PAN - 2水平均升高（平均：2835单位/毫升），平均比临床参数显示疾病进展迹象提前2个月。连续测定DU - PAN - 2是胰腺癌进展的敏感监测指标，可能作为治疗反应的早期指标。
