Okuyama S, Aihara H
Arch Int Pharmacodyn Ther. 1985 Jul;276(1):133-41.
Evoked potentials were recorded from the ventrobasal (VB) thalamus in normal and adjuvant arthritic rats anaesthetized with urethane (1200 mg/kg, i.p.). Effects of morphine and indomethacin on the evoked potentials elicited by transcutaneous electrical stimulation (TES) or tibial nerve electrical stimulation (TNES) were investigated. Morphine (1-3 mg/kg, i.v.) significantly depressed the potentials evoked by TES an TNES, in both groups. The magnitudes of the depressant effect of morphine were roughly equivalent, in each experiment. In normal rats, indomethacin (3-10 mg/kg, i.v.) significantly depressed the evoked potentials elicited by TES, but did not depress the evoked potentials elicited by TNES. In adjuvant arthritic rats, indomethacin (1-10 mg/kg, i.v.) depressed the evoked potentials elicited by TES and also, be it less readily, those elicited by TNES effects were more readily produced by TES than by TNES. These results suggest that the site of action of indomethacin differs in normal and adjuvant arthritic rats. The central antinociceptive action of indomethacin is clearly detectable in the presence of chronic inflammation. The antinociceptive action of morphine may reside in the neo-spinothalamic projection system, in both groups of rats.
在使用氨基甲酸乙酯（1200毫克/千克，腹腔注射）麻醉的正常大鼠和佐剂性关节炎大鼠中，记录腹侧基底（VB）丘脑的诱发电位。研究了吗啡和吲哚美辛对经皮电刺激（TES）或胫神经电刺激（TNES）诱发的诱发电位的影响。两组中，吗啡（1-3毫克/千克，静脉注射）均显著抑制TES和TNES诱发的电位。在每个实验中，吗啡的抑制作用幅度大致相当。在正常大鼠中，吲哚美辛（3-10毫克/千克，静脉注射）显著抑制TES诱发的诱发电位，但不抑制TNES诱发的诱发电位。在佐剂性关节炎大鼠中，吲哚美辛（1-10毫克/千克，静脉注射）抑制TES诱发的诱发电位，也抑制TNES诱发的诱发电位，不过程度较轻，且TES诱发的效应比TNES更易产生。这些结果表明，吲哚美辛在正常大鼠和佐剂性关节炎大鼠中的作用部位不同。在存在慢性炎症的情况下，吲哚美辛的中枢性抗伤害感受作用清晰可测。在两组大鼠中，吗啡的抗伤害感受作用可能存在于新脊髓丘脑投射系统中。
