Kayser V, Benoist J M, Guilbaud G
Brain Res. 1983 May 9;267(1):187-91. doi: 10.1016/0006-8993(83)91057-0.
The effects of various i.v. morphine doses (30, 100 and 1000 micrograms/kg) were studied upon unitary ventral basal (VB) neuronal responses elicited by joint stimulation in 24 Freund's adjuvant induced arthritic rats. The depressive effect of morphine was significantly dose-related and generally naloxone-reversible; however there were sometimes some difficulties to reverse morphine effect with the lowest dose of naloxone (10 micrograms/kg). The effect of morphine was not significantly different from that obtained in normal rats upon responses of specific nociceptive VB neurons. Although these results do not explain enhancement of morphine analgesia in arthritic rats by comparison with normal rats, they do confirm efficiency of low doses of morphine upon VB neuronal responses elicited by stimuli which induce nociceptive reaction in freely moving animals.
在24只弗氏佐剂诱导的关节炎大鼠中，研究了静脉注射不同剂量吗啡（30、100和1000微克/千克）对关节刺激引起的单一腹侧基底（VB）神经元反应的影响。吗啡的抑制作用具有显著的剂量相关性，且一般可被纳洛酮逆转；然而，有时用最低剂量的纳洛酮（10微克/千克）逆转吗啡作用会遇到一些困难。在特定伤害性VB神经元的反应方面，吗啡的作用与正常大鼠中所观察到的作用无显著差异。虽然这些结果无法解释与正常大鼠相比关节炎大鼠中吗啡镇痛作用增强的原因，但它们确实证实了低剂量吗啡对自由活动动物中诱发伤害性反应的刺激所引起的VB神经元反应具有有效性。
