Drago F, Scapagnini U
Arch Int Pharmacodyn Ther. 1985 Aug;276(2):271-8.
The behavioral effects of drugs stimulating prolactin (PRL) secretion have been studied in male rats. Acquisition of active avoidance behavior was facilitated by short- (SHPRL) and long-term hyperprolactinaemia (LHPRL) induced by pituitary homografts under the kidney capsule. Dopamine antagonists, such as haloperidol and bromperidol, though causing hyperprolactinaemia, suppressed the acquisition of active avoidance behavior. Sulpiride was not effective in this respect. SHPRL facilitated and LHPRL inhibited sexual behavior of male rats. Haloperidol, but not sulpiride, suppressed sexual capacity of these animals. Sulpiride and domperidone, but not haloperidol, increased locomotor activity of male rats. These data suggest that differences in the behavioral effects of dopamine antagonists may depend on their capacity to compete with PRL at the central level.
已在雄性大鼠中研究了刺激催乳素（PRL）分泌的药物的行为效应。肾囊下垂体移植诱导的短期高催乳素血症（SHPRL）和长期高催乳素血症（LHPRL）促进了主动回避行为的习得。多巴胺拮抗剂，如氟哌啶醇和溴哌利多，虽然会引起高催乳素血症，但会抑制主动回避行为的习得。舒必利在这方面无效。SHPRL促进而LHPRL抑制雄性大鼠的性行为。氟哌啶醇而非舒必利抑制了这些动物的性能力。舒必利和多潘立酮而非氟哌啶醇增加了雄性大鼠的运动活性。这些数据表明，多巴胺拮抗剂行为效应的差异可能取决于它们在中枢水平与PRL竞争的能力。
