Xue Hongkun, Shi Zhangmeng, Ji Lihong, Yang Jiacheng, Yu Hao, Tan Jiaqi
College of Traditional Chinese Medicine, Hebei University, No. 342 Yuhua East Road, Lianchi District, Baoding 071002, China.
School of Basic Medical Sciences, Hebei University, No. 342 Yuhua East Road, Lianchi District, Baoding 071002, China.
Int J Biol Macromol. 2025 Aug;319(Pt 1):145237. doi: 10.1016/j.ijbiomac.2025.145237. Epub 2025 Jun 16.
Wound management is a major challenge worldwide, imposing a substantial financial burden on the governments of every country. In recent years, numerous studies have focused on wound dressings that promoted wound healing. Notably, traditional wound dressings (tourniquets, gauze, and bandages) do not respond well to the wound healing process, resulting in poor wound healing. Polysaccharide-based materials (chitosan, sodium alginate, pectin, starch, and cellulose, etc.) are expected to be developed as potential wound dressings due to their low toxicity, good biodegradability, biocompatibility, adhesion, and loading properties. Growing studies have confirmed that polysaccharide-based wound dressings (PWDs) could provide a moist healing environment, promote wound healing, and reduce the risk of infection. An in-depth exploration of the physicochemical and functional properties of PWDs holds significant guiding importance for the designing of PWDs with specific functionalities. Hence, this review systematically introduces the PWDs types. Moreover, this paper comprehensively reviews the physicochemical and functional properties of PWDs. Furthermore, this review also outlines the application of PWDs for different types of wounds. The findings provide valuable insights and guidance for the further development and utilization of PWDs.
伤口管理是全球面临的一项重大挑战，给每个国家的政府带来了沉重的财政负担。近年来，众多研究聚焦于促进伤口愈合的伤口敷料。值得注意的是，传统伤口敷料（止血带、纱布和绷带）对伤口愈合过程反应不佳，导致伤口愈合不良。基于多糖的材料（壳聚糖、海藻酸钠、果胶、淀粉和纤维素等）因其低毒性、良好的生物降解性、生物相容性、粘附性和负载性能，有望被开发为潜在的伤口敷料。越来越多的研究证实，基于多糖的伤口敷料（PWDs）可以提供湿润的愈合环境，促进伤口愈合，并降低感染风险。深入探究PWDs的物理化学和功能特性对设计具有特定功能的PWDs具有重要的指导意义。因此，本综述系统地介绍了PWDs的类型。此外，本文全面综述了PWDs的物理化学和功能特性。此外，本综述还概述了PWDs在不同类型伤口中的应用。这些研究结果为PWDs的进一步开发和利用提供了有价值的见解和指导。
