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本文引用的文献

1
Drug delivery strategies to cross the blood-brain barrier in Alzheimer's disease: a comprehensive review on three promising strategies.阿尔茨海默病中跨越血脑屏障的药物递送策略：对三种有前景策略的全面综述
J Prev Alzheimers Dis. 2025 Aug;12(7):100204. doi: 10.1016/j.tjpad.2025.100204. Epub 2025 May 19.
2
Targeting the transferrin receptor to transport antisense oligonucleotides across the mammalian blood-brain barrier.针对转铁蛋白受体将反义寡核苷酸转运穿过哺乳动物血脑屏障。
Sci Transl Med. 2024 Aug 14;16(760):eadi2245. doi: 10.1126/scitranslmed.adi2245.
3
Identification and in vivo characterization of a brain-penetrating nanobody.鉴定和体内鉴定一种可穿透血脑屏障的纳米抗体。
Fluids Barriers CNS. 2020 Oct 14;17(1):62. doi: 10.1186/s12987-020-00226-z.
4
Boosting brain uptake of a therapeutic antibody by reducing its affinity for a transcytosis target.通过降低治疗性抗体对转胞吞作用靶点的亲和力来提高其脑内摄取。
Sci Transl Med. 2011 May 25;3(84):84ra44. doi: 10.1126/scitranslmed.3002230.
5
The blood-brain barrier: bottleneck in brain drug development.血脑屏障：脑药物研发的瓶颈
NeuroRx. 2005 Jan;2(1):3-14. doi: 10.1602/neurorx.2.1.3.
6
Noninvasive MR imaging-guided focal opening of the blood-brain barrier in rabbits.兔血脑屏障的无创磁共振成像引导下局灶性开放
Radiology. 2001 Sep;220(3):640-6. doi: 10.1148/radiol.2202001804.
7
The effect of particle size and charge on the clearance rates of liposomes and liposome encapsulated drugs.粒径和电荷对脂质体及脂质体包封药物清除率的影响。
Biochem Biophys Res Commun. 1975 Apr 7;63(3):651-8. doi: 10.1016/s0006-291x(75)80433-5.

Breaking Barriers: Delivering Therapeutics to the Brain in Alzheimer's Disease.

作者信息

De Strooper Bart, Scheltens Philip, Salloway Stephen

机构信息

Center for Brain and Disease research at VIB@KULeuven, University of Leuven, Belgium and Laboratory of the cellular phase of Alzheimer's Disease at UKDRI@University College London, UCL, UK.

EQT Life Sciences, Amsterdam, The Netherlands.

出版信息

J Prev Alzheimers Dis. 2025 Aug;12(7):100229. doi: 10.1016/j.tjpad.2025.100229. Epub 2025 Jun 13.

DOI:10.1016/j.tjpad.2025.100229
PMID:40517082
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12321621/
Abstract
摘要