Pang S C, Scott T M
Artery. 1985;12(6):382-7.
The hypothesis that arterial medial hypertrophy occurs in the SHR due to genetic factors inherent to the arterial wall, was examined in jejunal arteries cross transplanted between four-week-old SHR and WKY rats as a shunt between the femoral artery and vein. Four weeks after transplant, the arteries were removed and processed for embedding in resin and measurement of wall parameters by light microscopy. It was determined that irrespective of the origin of the transplanted artery, the wall thickness of transplants was higher in SHR hosts than in WKY hosts. Taken with results from other studies, this suggests that genetic factors inherent to the arterial wall are not the cause of arterial hypertrophy in the SHR.
关于自发性高血压大鼠（SHR）动脉中层肥厚是由动脉壁固有遗传因素所致的假说，通过在四周龄的SHR和WKY大鼠之间交叉移植空肠动脉作为股动脉和静脉之间的分流来进行研究。移植四周后，取出动脉并进行处理，以嵌入树脂并通过光学显微镜测量壁参数。结果确定，无论移植动脉的来源如何，SHR宿主中移植动脉的壁厚度均高于WKY宿主。结合其他研究结果，这表明动脉壁固有遗传因素不是SHR动脉肥厚的原因。
