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[心肌术中保护效果的结构与生化特征]

[Structural and biochemical characteristics of the effectiveness of intraoperative protection of the myocardium].

作者信息

Mogilevskiĭ G M, Sharov V G, Saks V A, Semenovskiĭ M L

出版信息

Arkh Patol. 1985;47(6):24-9.

PMID:4051803
Abstract

Results of morphological and biochemical examination of 153 myocardium biopsies from 42 patients with the intraoperational heart ischemia that developed during the correction of cardiac valves disturbances under the condition of artificial circulation and cardioplegia with the blood based solution are given. Phosphocreatin ("neoton" produced by Schiapparelli Company, Italy) was added as a cardioprotector to the cardioplegic solution in 24 patients. The high efficiency of the drugs for the cardiomyocytes sarcolemma is shown by means of colloidal lanthanum. A full retention of the macroergic phosphates is also shown biochemically when the standard solution was modified for the heart protection.

摘要

给出了42例在人工循环和使用含血溶液的心脏停搏情况下,矫正心脏瓣膜紊乱时发生术中心脏缺血患者的153份心肌活检的形态学和生化检查结果。24例患者在心脏停搏液中添加了磷酸肌酸(意大利Schiapparelli公司生产的“neoton”)作为心脏保护剂。通过胶体镧显示了这些药物对心肌细胞膜的高效性。当对标准溶液进行心脏保护改良时,生化检查还显示高能磷酸盐完全得以保留。

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