[Prophylaxis of Rh-sensitisation by intravenous IgG anti-D (author's transl)].

During 1971 and 1972 1109 rh-negative mothers with an Rh-positive child were treated with an intravenous standard dose of 80-120 microng of IgG anti-D. To achieve complete elimination of fetal erythrocytes within 72 hours after the first immunoglobulin injection this standard dose had to be increased in 14% of the women. In 1973 and 1974 1138 rh-negative mothers of Rh-positive children were treated with an intravenous standard dose of 240 microng of IgG anti-D. This dose was insufficient in only 1.2% of the rh-negative mothers. More than 98.8% of all women are protected by a standard intravenous dose of 240 microng of IgG anti-D and a single erythrocyte elimination control 72 hours after the birth. It appears that the results after intravenous immunoglobulin are as a whole significantly better than after intramuscular IgG anti-D.