Jia Meng, Han Shuangxu, Li Liang, Fu Yi, Zhou Di
Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.
Kidney Dis (Basel). 2025 May 2;11(1):390-401. doi: 10.1159/000546141. eCollection 2025 Jan-Dec.
Kidney diseases are a prevalent global health concern, and despite ongoing research, there remains a lack of fully effective clinical treatments to prevent or halt their progression. Consequently, it is encouraged to identify novel biomarkers, establish early diagnostic methods, pinpoint key molecular pathways, and develop innovative therapeutic targets for more effective management of renal disorders.
Interferons (IFNs), a group of cytokines, play pivotal roles in immune responses, particularly in antiviral and antiproliferative activities. IFNs trigger a cascade of signaling events that lead to the induction of interferon-stimulated genes (ISGs), which are essential for controlling viral infections and regulating immune responses. This review explores the impact of interferon-related genes on renal disorders, focusing on the mechanisms, therapeutic approaches, and consequences of enhanced interferon signaling in the kidney.
Most diagnostic and therapeutic strategies targeting ISGs are still far from clinical implementation. The better understanding of ISG-regulated pathophysiology and the progress of new intervention approaches are expected to facilitate the clinical translation of ISGs-based diagnosis and therapy of kidney diseases.
肾脏疾病是全球普遍关注的健康问题，尽管研究不断，但仍缺乏完全有效的临床治疗方法来预防或阻止其进展。因此，鼓励识别新型生物标志物、建立早期诊断方法、确定关键分子途径并开发创新治疗靶点，以更有效地管理肾脏疾病。
干扰素（IFNs）是一类细胞因子，在免疫反应中起关键作用，尤其是在抗病毒和抗增殖活动中。干扰素引发一系列信号事件，导致干扰素刺激基因（ISGs）的诱导，这些基因对于控制病毒感染和调节免疫反应至关重要。本综述探讨了干扰素相关基因对肾脏疾病的影响，重点关注肾脏中干扰素信号增强的机制、治疗方法及后果。
大多数针对ISGs的诊断和治疗策略仍远未实现临床应用。对ISG调节的病理生理学的更好理解以及新干预方法的进展有望促进基于ISGs的肾脏疾病诊断和治疗的临床转化。
