Coathup Victoria, Carson Claire, Ashdown Helen, Santorelli Gillian, Quigley Maria A
National Perinatal Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Nuffield Department of Primary Health Care Sciences, University of Oxford, Oxford, UK.
BMJ Med. 2025 Jun 3;4(1):e001050. doi: 10.1136/bmjmed-2024-001050. eCollection 2025.
To investigate the relation between maternal body mass index and hospital admissions for infections in their offspring, and to identify potentially modifiable mediators.
Longitudinal cohort study.
Born in Bradford longitudinal, multi-ethnic birth cohort, Bradford, UK. Secondary analysis linked to routine hospital admission data, January 2007 to 3 October 2022.
9540 singleton births between 2007 and 2011, born to 9037 mothers, followed up from birth to about age 15 years.
Total number of hospital admissions related to infections, between birth and age 15 years, in age categories <1 year, 1-4 years, and 5-15 years.
The main study cohort comprised 9540 children and 9037 mothers. About 56% of mothers were overweight or obese. First trimester maternal body mass index was positively associated with rates of hospital admissions for infection across all ages, but associations were significant (P<0.05) only for children born to women with the highest body mass index (obesity grades 2-3). Compared with women with a healthy body mass index, children born to women with obesity grades 2-3 had an adjusted rate ratio of 1.41 (95% confidence interval 1.13 to 1.77) at <1 year and an adjusted rate ratio of 1.53 (1.19 to 1.98) for hospital admissions for infection by age 5-15 years. Similar trends were seen for respiratory and gastrointestinal infections, and multisystem viral infections. Being born by caesarean section and child obesity at aged 4-5 years accounted for 21% and 26% of the association, respectively.
In this study, a modest but consistent association between maternal obesity (grades 2-3) and hospital admissions for infection throughout childhood was found. Healthcare professionals and public health campaigns should continue to support mothers to achieve and maintain a healthy body weight before conception and during the postpartum period.
研究母亲体重指数与后代感染相关住院情况之间的关系，并确定可能可改变的中介因素。
纵向队列研究。
出生于英国布拉德福德的纵向、多民族出生队列。与2007年1月至2022年10月3日的常规住院数据进行二次分析。
2007年至2011年间9037名母亲所生的9540例单胎出生，从出生随访至约15岁。
出生至15岁期间，年龄<1岁、1 - 4岁和5 - 15岁年龄段与感染相关的住院总数。
主要研究队列包括9540名儿童和9037名母亲。约56%的母亲超重或肥胖。孕早期母亲体重指数与各年龄段感染相关住院率呈正相关，但仅在体重指数最高（肥胖2 - 3级）的母亲所生儿童中相关性显著（P<0.05）。与体重指数健康的女性相比，肥胖2 - 3级女性所生儿童在<1岁时调整后的发病率比值为1.41（95%置信区间1.13至1.77），5 - 15岁时感染相关住院的调整发病率比值为1.53（1.19至1.98）。呼吸道和胃肠道感染以及多系统病毒感染也呈现类似趋势。剖宫产出生和4 - 5岁儿童肥胖分别占该关联的21%和26%。
在本研究中，发现母亲肥胖（2 - 3级）与儿童期感染相关住院之间存在适度但一致的关联。医疗保健专业人员和公共卫生运动应继续支持母亲在受孕前和产后达到并维持健康体重。
