Hamid Yameen, Sarkar Md Al Amin, Karmaker Sudip, Nowrin Samarea, Amanat Ullah S M
Stem Cell and Translational Neurology, University of Edinburgh, Edinburgh, GBR.
Acute Medicine, Medway NHS Foundation Trust, Gillingham, GBR.
Cureus. 2025 May 15;17(5):e84167. doi: 10.7759/cureus.84167. eCollection 2025 May.
We report a rare case of late-onset hypocalcaemia presenting with seizure in a female patient, occurring approximately 25 years after a total thyroidectomy. Initial investigations ruled out intracranial pathology, and biochemical analysis confirmed severe hypocalcaemia. The patient responded to intravenous calcium gluconate infusion, with subsequent stabilisation on oral calcium therapy. Notably, the patient had been non-compliant with long-term calcium supplementation. This report underscores that chronic hypocalcaemia can manifest with acute neurological symptoms such as seizures and highlights the importance of long-term follow-up for post-thyroidectomy patients.
我们报告了一例罕见的迟发性低钙血症病例,该病例发生在一名女性患者身上,表现为癫痫发作,发生在全甲状腺切除术后约25年。初步检查排除了颅内病变,生化分析证实存在严重低钙血症。患者对静脉输注葡萄糖酸钙有反应,随后通过口服钙剂治疗病情稳定。值得注意的是,该患者一直未遵医嘱长期补充钙剂。本报告强调慢性低钙血症可表现为癫痫发作等急性神经症状,并突出了甲状腺切除术后患者长期随访的重要性。