Virú-Loza Manuel André, Bermudez-Paredes Francesca, Arauco-Carhuas Isabel Milagros
Unidad de Revisiones Sistemáticas y Meta-análisis, Vicerrectorado de Investigación, Universidad San Ignacio de Loyola, Lima, Peru.
ADIECS Asociación para el Desarrollo de la Investigación Estudiantil en Ciencias de la Salud, Universidad Nacional Mayor de San Marcos, Lima, Peru.
SAGE Open Med Case Rep. 2025 Jun 13;13:2050313X251347787. doi: 10.1177/2050313X251347787. eCollection 2025.
Congenital hyperinsulinism is characterized by dysregulated insulin secretion and is the most common and severe cause of persistent hypoglycemia in pediatrics. Brain damage rates can be as high as 50% due to inadequate treatment. Transient congenital hyperinsulinism is more frequent than permanent congenital hyperinsulinism. Acquired hyperinsulinism due to perinatal stress is often transient, too. Diazoxide is the first-line therapy. However, in Peru, reports about pediatric patients with hyperinsulinism treated with diazoxide are scarce. Our article describes the first Peruvian case series of severe transient neonatal hyperinsulinism treated with diazoxide, with good response and manageable adverse effects. Diazoxide should be included in the Single National Pharmaceutical Request Form for Essential Medicines of Peru to expedite the use of a medication as essential as this one.
先天性高胰岛素血症的特征是胰岛素分泌失调，是儿科持续性低血糖最常见和最严重的原因。由于治疗不充分，脑损伤率可高达50%。短暂性先天性高胰岛素血症比永久性先天性高胰岛素血症更常见。围产期应激导致的获得性高胰岛素血症通常也是短暂的。二氮嗪是一线治疗药物。然而，在秘鲁，关于用二氮嗪治疗高胰岛素血症儿科患者的报道很少。我们的文章描述了秘鲁首例用二氮嗪治疗严重短暂性新生儿高胰岛素血症的病例系列，反应良好且不良反应可控。二氮嗪应列入秘鲁基本药物国家单一药品申请表，以加快使用如此重要的药物。
