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两名患有Ia型糖原贮积病和先兆子痫患者的胎盘病理学

Placenta Pathologies in Two Patients With Glycogen Storage Disease Type Ia and Preeclampsia.

作者信息

Laufs V, Hasenburg A, Busch M A, Lang F, Macchiella D, Mildenberger E, Seidmann L, Hennermann J B

机构信息

Clinic for Obstetrics and Women's Health University Medical Center of the Johannes Gutenberg-University Mainz Mainz Germany.

Division of Neonatology Center for Pediatric and Adolescent Medicine, University Medical Center of the Johannes Gutenberg-University Mainz Mainz Germany.

出版信息

JIMD Rep. 2025 Jun 12;66(4):e70025. doi: 10.1002/jmd2.70025. eCollection 2025 Jul.

DOI:10.1002/jmd2.70025
PMID:40520136
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12162178/
Abstract

Little is known about pregnancies and placental changes in women with glycogen storage disease type Ia (GSD Ia). We report on two primipara with GSD Ia who both developed preeclampsia and whose newborns were small for gestational age. Both placentas showed sonomorphological and macroscopical abnormalities. Disease-specific histological features could not be identified, which should prompt further research.

摘要

关于Ia型糖原贮积病（GSD Ia）女性的妊娠情况和胎盘变化，人们所知甚少。我们报告了两名患有GSD Ia的初产妇，她们均发生了先兆子痫，且其新生儿均为小于胎龄儿。两个胎盘均显示出超声形态学和宏观异常。未发现疾病特异性组织学特征，这应促使进一步研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d570/12162178/e481ed08ee2f/JMD2-66-e70025-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d570/12162178/b0169a3d0ffb/JMD2-66-e70025-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d570/12162178/cb78cb9cd657/JMD2-66-e70025-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d570/12162178/529b1baaf5fe/JMD2-66-e70025-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d570/12162178/e481ed08ee2f/JMD2-66-e70025-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d570/12162178/b0169a3d0ffb/JMD2-66-e70025-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d570/12162178/cb78cb9cd657/JMD2-66-e70025-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d570/12162178/529b1baaf5fe/JMD2-66-e70025-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d570/12162178/e481ed08ee2f/JMD2-66-e70025-g002.jpg

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本文引用的文献

1
Multidisciplinary management of pregnancy and labour in a patient with glycogen storage disease type 1a.1a 型糖原贮积病患者妊娠和分娩的多学科管理。
BMJ Case Rep. 2021 Aug 11;14(8):e241161. doi: 10.1136/bcr-2020-241161.
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四种主要的胎盘损伤模式：理解和实施 2016 年阿姆斯特丹共识的逐步指南。
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Placental structure in gestational diabetes mellitus.妊娠期糖尿病的胎盘结构。
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A systematic review of placental pathology in maternal diabetes mellitus.妊娠糖尿病胎盘病理学的系统评价
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Diagnosis and management of glycogen storage disease type I: a practice guideline of the American College of Medical Genetics and Genomics.I型糖原贮积病的诊断与管理：美国医学遗传学与基因组学学会实践指南
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Pre-eclampsia is associated with, and preceded by, hypertriglyceridaemia: a meta-analysis.子痫前期与高甘油三酯血症有关，并发生在其之前：一项荟萃分析。
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