碱性多肽对大鼠心脏鸟氨酸脱羧酶的抑制作用。
Inhibition of rat heart ornithine decarboxylase by basic polypeptides.
作者信息
Flamigni F, Guarnieri C, Marmiroli S, Caldarera C M
出版信息
Biochem J. 1985 Aug 1;229(3):807-10. doi: 10.1042/bj2290807.
Abstract
Purified and partially purified ornithine decarboxylase (ODC) from rat heart was inhibited by basic polypeptides in vitro. Poly-L-arginine, the most effective, was inhibitory at a concentration as low as 0.1 microgram/ml; protamine and histone clearly inhibited ODC at concentrations higher than 2 micrograms/ml, but poly-L-lysine was less effective. The ability to inhibit ODC appeared to correlate with the arginine-residue content of basic polypeptides. The inhibition effect could be decreased by increasing substrate concentration and ionic strength.
摘要
从大鼠心脏中纯化和部分纯化的鸟氨酸脱羧酶（ODC）在体外受到碱性多肽的抑制。最有效的聚-L-精氨酸在低至0.1微克/毫升的浓度下就具有抑制作用；鱼精蛋白和组蛋白在浓度高于2微克/毫升时能明显抑制ODC，但聚-L-赖氨酸的效果较差。抑制ODC的能力似乎与碱性多肽的精氨酸残基含量相关。增加底物浓度和离子强度可降低抑制作用。
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本文引用的文献
1
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J Cell Physiol. 1981 May;107(2):209-17. doi: 10.1002/jcp.1041070206.
2
Posttranslationally modified ornithine decarboxylase may regulate RNA polymerase I activity.翻译后修饰的鸟氨酸脱羧酶可能调节RNA聚合酶I的活性。
Biochem Pharmacol. 1982 Nov 1;31(21):3373-8. doi: 10.1016/0006-2952(82)90614-1.
3
Ornithine decarboxylase activity in nucleolus and nucleoplasm demonstrated autoradiographically with tritium-labeled alpha-difluoromethylornithine.用氚标记的α-二氟甲基鸟氨酸通过放射自显影法显示核仁和核质中的鸟氨酸脱羧酶活性。
Cell Biol Int Rep. 1982 Oct;6(10):951-4. doi: 10.1016/0309-1651(82)90006-6.
4
Inhibition of ornithine decarboxylase and glutamic acid decarboxylase activities by phosphorylethanolamine and phosphorylcholine.
Biochem Biophys Res Commun. 1984 Jul 18;122(1):277-82. doi: 10.1016/0006-291x(84)90471-6.
5
Antizyme to ornithine decarboxylase is present in the liver of starved rats.饥饿大鼠肝脏中存在鸟氨酸脱羧酶抗酶。
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6
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7
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