磷酸柠檬酸对原代培养的大鼠主动脉平滑肌细胞摄取45Ca2+的抑制作用。
Phosphocitrate inhibition of 45Ca2+ uptake in rat aortic smooth muscle cells in primary culture.
作者信息
Shankar R, Sallis J D
出版信息
Biochem Biophys Res Commun. 1985 Sep 16;131(2):793-9. doi: 10.1016/0006-291x(85)91309-9.
Phosphocitrate inhibits 45Ca2+ uptake by rat aortic smooth muscle cells in primary culture. Unlike the Ca2+ channel blocking effect of diltiazem, the phosphocitrate effect is neither time dependent nor reliant on a depolarized membrane. Phosphocitrate and diltiazem together in maximum inhibitory concentration show an additive effect. The data suggest that different Ca2+ uptake mechanisms are involved. The potential exists for phosphocitrate to have a therapeutic role in atherogenesis through modulating Ca2+ movements in arterial smooth muscle.
磷酸柠檬酸抑制原代培养的大鼠主动脉平滑肌细胞摄取45Ca2+。与地尔硫䓬的钙通道阻滞作用不同，磷酸柠檬酸的作用既不依赖时间，也不依赖于去极化膜。磷酸柠檬酸和地尔硫䓬以最大抑制浓度共同作用时表现出相加效应。数据表明涉及不同的钙摄取机制。磷酸柠檬酸有可能通过调节动脉平滑肌中的钙运动在动脉粥样硬化形成中发挥治疗作用。
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