• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

来自肽GTSFTTTAER通过多途径调节减轻斑马鱼模型中三硝基苯磺酸诱导的炎症性肠病。

Peptide GTSFTTTAER From Alleviates TNBS-Induced Inflammatory Bowel Disease in a Zebrafish Model via Multi-Pathway Regulation.

作者信息

Wang Qifei, Xu Fenghua, Cao Yongna, Li Bin, Zhang Shanshan, Zhang Yun

机构信息

Biology Institute Qilu University of Technology (Shandong Academy of Sciences) Jinan China.

Research Center of Translational Medicine Central Hospital Affiliated to Shandong First Medical University Jinan China.

出版信息

Food Sci Nutr. 2025 Jun 12;13(6):e70427. doi: 10.1002/fsn3.70427. eCollection 2025 Jun.

DOI:10.1002/fsn3.70427
PMID:40521083
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12162357/
Abstract

Inflammatory bowel disease (IBD) is a refractory chronic intestinal disease caused by immune dysfunction, with an unknown pathogenesis. In this study, the peptide GTSFTTTAER was isolated from for treatment of IBD for the first time. We examined its protective effects on a zebrafish model of 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced IBD. The results indicate that the peptide GTSFTTTAER ameliorates intestinal inflammatory injury by reducing the number of immune cells at the intestinal site and increasing the frequency of intestinal peristalsis. Besides, in order to predict and verify the potential mechanism of the anti-inflammatory effects of peptide GTSFTTTAER, we performed transcriptome and reverse transcription-quantitative polymerase chain reaction analysis. The transcriptome analysis revealed that the key pathways for the potential protective effects of GTSFTTTAER were the Toll-like receptor signaling pathway and the necroptosis pathway. Lastly, molecular docking technology further confirmed the action target of peptide GTSFTTTAER. In conclusion, GTSFTTTAER has a beneficial effect on IBD in TNBS-induced zebrafish. Our study will provide a valuable reference for the utilization of peptide GTSFTTTAER from , and it may also be helpful in developing therapeutic agents for IBD.

摘要

炎症性肠病（IBD）是一种由免疫功能障碍引起的难治性慢性肠道疾病，其发病机制尚不清楚。在本研究中，首次从[具体来源未提及]中分离出肽GTSFTTTAER用于治疗IBD。我们检测了其对2,4,6-三硝基苯磺酸（TNBS）诱导的IBD斑马鱼模型的保护作用。结果表明，肽GTSFTTTAER通过减少肠道部位免疫细胞数量和增加肠道蠕动频率来改善肠道炎症损伤。此外，为了预测和验证肽GTSFTTTAER抗炎作用的潜在机制，我们进行了转录组和逆转录定量聚合酶链反应分析。转录组分析显示，GTSFTTTAER潜在保护作用的关键途径是Toll样受体信号通路和坏死性凋亡途径。最后，分子对接技术进一步证实了肽GTSFTTTAER的作用靶点。总之，GTSFTTTAER对TNBS诱导的斑马鱼IBD具有有益作用。我们的研究将为[具体来源未提及]中肽GTSFTTTAER的利用提供有价值的参考，也可能有助于开发IBD治疗药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e54/12162357/e258589a8a45/FSN3-13-e70427-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e54/12162357/359b543b7cc9/FSN3-13-e70427-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e54/12162357/df54979b2d51/FSN3-13-e70427-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e54/12162357/08a2086056a0/FSN3-13-e70427-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e54/12162357/ca2456eff022/FSN3-13-e70427-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e54/12162357/1ea099e2f5c6/FSN3-13-e70427-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e54/12162357/1b14329f4b86/FSN3-13-e70427-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e54/12162357/dc7ad500a9e0/FSN3-13-e70427-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e54/12162357/6819e40159d5/FSN3-13-e70427-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e54/12162357/820449f0cccb/FSN3-13-e70427-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e54/12162357/e258589a8a45/FSN3-13-e70427-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e54/12162357/359b543b7cc9/FSN3-13-e70427-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e54/12162357/df54979b2d51/FSN3-13-e70427-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e54/12162357/08a2086056a0/FSN3-13-e70427-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e54/12162357/ca2456eff022/FSN3-13-e70427-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e54/12162357/1ea099e2f5c6/FSN3-13-e70427-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e54/12162357/1b14329f4b86/FSN3-13-e70427-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e54/12162357/dc7ad500a9e0/FSN3-13-e70427-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e54/12162357/6819e40159d5/FSN3-13-e70427-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e54/12162357/820449f0cccb/FSN3-13-e70427-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e54/12162357/e258589a8a45/FSN3-13-e70427-g009.jpg

相似文献

1
Peptide GTSFTTTAER From Alleviates TNBS-Induced Inflammatory Bowel Disease in a Zebrafish Model via Multi-Pathway Regulation.来自肽GTSFTTTAER通过多途径调节减轻斑马鱼模型中三硝基苯磺酸诱导的炎症性肠病。
Food Sci Nutr. 2025 Jun 12;13(6):e70427. doi: 10.1002/fsn3.70427. eCollection 2025 Jun.
2
The Peptide LLTRAGL Derived from Exerts Protective Effect against Inflammatory Bowel Disease in Zebrafish Model by Regulating Multi-Pathways.来源于 的肽 LLTRAGL 通过调节多通路在斑马鱼模型中发挥对炎症性肠病的保护作用。
Mar Drugs. 2024 Feb 22;22(3):100. doi: 10.3390/md22030100.
3
The alleviative effect of C-phycocyanin peptides against TNBS-induced inflammatory bowel disease in zebrafish via the MAPK/Nrf2 signaling pathways.C-藻蓝蛋白肽通过 MAPK/Nrf2 信号通路对斑马鱼 TNBS 诱导的炎症性肠病的缓解作用。
Fish Shellfish Immunol. 2024 Feb;145:109351. doi: 10.1016/j.fsi.2023.109351. Epub 2024 Jan 1.
4
Methyl 3-Bromo-4,5-dihydroxybenzoate Attenuates Inflammatory Bowel Disease by Regulating TLR/NF-κB Pathways.3-溴-4,5-二羟基苯甲酸甲酯通过调节TLR/NF-κB信号通路减轻炎症性肠病
Mar Drugs. 2025 Jan 19;23(1):47. doi: 10.3390/md23010047.
5
Radix Panacis quinquefolii Extract Ameliorates Inflammatory Bowel Disease through Inhibiting Inflammation.西洋参提取物通过抑制炎症改善炎症性肠病。
Chin J Integr Med. 2023 Sep;29(9):825-831. doi: 10.1007/s11655-022-3543-6. Epub 2022 Dec 17.
6
Soluble Protein Hydrolysate Ameliorates Gastrointestinal Inflammation and Injury in 2,4,6-Trinitrobenzene Sulfonic Acid-Induced Colitis in Mice.可溶性蛋白水解物可改善 2,4,6-三硝基苯磺酸诱导的小鼠结肠炎的胃肠道炎症和损伤。
Biomolecules. 2022 Sep 13;12(9):1287. doi: 10.3390/biom12091287.
7
Role of gut microbiota in a zebrafish model with chemically induced enterocolitis involving toll-like receptor signaling pathways.肠道微生物群在化学诱导的涉及Toll样受体信号通路的斑马鱼小肠结肠炎模型中的作用
Zebrafish. 2014 Jun;11(3):255-64. doi: 10.1089/zeb.2013.0917. Epub 2014 Apr 23.
8
Intestinal upregulation of melanin-concentrating hormone in TNBS-induced enterocolitis in adult zebrafish.成年斑马鱼中 TNBS 诱导的结肠炎中肠内黑色素浓缩激素的上调。
PLoS One. 2013 Dec 20;8(12):e83194. doi: 10.1371/journal.pone.0083194. eCollection 2013.
9
Sodium Butyrate Inhibits Inflammation and Maintains Epithelium Barrier Integrity in a TNBS-induced Inflammatory Bowel Disease Mice Model.丁酸钠抑制三硝基苯磺酸诱导的炎症性肠病小鼠模型中的炎症反应并维持肠上皮屏障完整性。
EBioMedicine. 2018 Apr;30:317-325. doi: 10.1016/j.ebiom.2018.03.030. Epub 2018 Mar 28.
10
Preparation of enzymatic hydrolysates of mulberry leaf flavonoids and investigation into its treatment and mechanism for zebrafish inflammatory bowel disease.桑叶黄酮类化合物酶解产物的制备及其治疗斑马鱼炎症性肠病的作用与机制研究。
Fish Shellfish Immunol. 2024 Nov;154:109960. doi: 10.1016/j.fsi.2024.109960. Epub 2024 Oct 10.

引用本文的文献

1
Efficient Hydrolysis of Earthworm Protein and the Lipid-Lowering Mechanism of Peptides in the Hydrolysate.蚯蚓蛋白的高效水解及水解产物中肽的降脂机制
Foods. 2025 Jul 1;14(13):2338. doi: 10.3390/foods14132338.

本文引用的文献

1
Preparation of enzymatic hydrolysates of mulberry leaf flavonoids and investigation into its treatment and mechanism for zebrafish inflammatory bowel disease.桑叶黄酮类化合物酶解产物的制备及其治疗斑马鱼炎症性肠病的作用与机制研究。
Fish Shellfish Immunol. 2024 Nov;154:109960. doi: 10.1016/j.fsi.2024.109960. Epub 2024 Oct 10.
2
Antimicrobial peptides: Opportunities and challenges in overcoming resistance.抗菌肽：克服耐药性的机遇与挑战。
Microbiol Res. 2024 Sep;286:127822. doi: 10.1016/j.micres.2024.127822. Epub 2024 Jun 26.
3
An immunohistochemical atlas of necroptotic pathway expression.
坏死性凋亡通路表达的免疫组化图谱。
EMBO Mol Med. 2024 Jul;16(7):1717-1749. doi: 10.1038/s44321-024-00074-6. Epub 2024 May 15.
4
The Peptide LLTRAGL Derived from Exerts Protective Effect against Inflammatory Bowel Disease in Zebrafish Model by Regulating Multi-Pathways.来源于 的肽 LLTRAGL 通过调节多通路在斑马鱼模型中发挥对炎症性肠病的保护作用。
Mar Drugs. 2024 Feb 22;22(3):100. doi: 10.3390/md22030100.
5
The alleviative effect of C-phycocyanin peptides against TNBS-induced inflammatory bowel disease in zebrafish via the MAPK/Nrf2 signaling pathways.C-藻蓝蛋白肽通过 MAPK/Nrf2 信号通路对斑马鱼 TNBS 诱导的炎症性肠病的缓解作用。
Fish Shellfish Immunol. 2024 Feb;145:109351. doi: 10.1016/j.fsi.2023.109351. Epub 2024 Jan 1.
6
A nanoparticle platform for combined mucosal healing and immunomodulation in inflammatory bowel disease treatment.一种用于炎症性肠病治疗中联合黏膜愈合和免疫调节的纳米颗粒平台。
Bioact Mater. 2023 Oct 11;32:206-221. doi: 10.1016/j.bioactmat.2023.09.014. eCollection 2024 Feb.
7
Immunotoxicity and transcriptome analysis of zebrafish embryos exposure to Nitazoxanide.硝唑尼特暴露于斑马鱼胚胎的免疫毒性和转录组分析。
Fish Shellfish Immunol. 2023 Oct;141:108977. doi: 10.1016/j.fsi.2023.108977. Epub 2023 Aug 12.
8
Heat stress-induced intestinal epithelial cells necroptosis via TLR3-TRIF-RIP3 pathway was dependent on p53.热应激诱导的肠道上皮细胞坏死通过 TLR3-TRIF-RIP3 途径依赖于 p53。
Int Immunopharmacol. 2023 Sep;122:110574. doi: 10.1016/j.intimp.2023.110574. Epub 2023 Jul 6.
9
Nothobranchius as a model for anorexia of aging research: an evolutionary, anatomical, histological, immunohistochemical, and molecular study.以非洲攀鲈为模型研究衰老相关性厌食症：一项进化、解剖、组织学、免疫组织化学和分子研究。
Ann Anat. 2023 Oct;250:152116. doi: 10.1016/j.aanat.2023.152116. Epub 2023 Jun 9.
10
Pathophysiology of Inflammatory Bowel Disease: Innate Immune System.炎症性肠病的病理生理学：固有免疫系统。
Int J Mol Sci. 2023 Jan 12;24(2):1526. doi: 10.3390/ijms24021526.