Shaw G K, Spence M
Alcohol Alcohol. 1985;20(2):243-9.
A minority of alcoholics will show obvious evidence of dementia but the majority will appear clinically intact. Despite the fact that almost 50% of those 'intact' alcoholics will be found to have structural brain damage, on routine tests of intelligence they will fall in the normal range. More detailed psychometric testing will however reveal deficits in non-verbal abstracting ability, tactile performance and psychomotor speed with a perceptual component. Neither consumption variables nor the extent of structural brain damage are closely related to the degree of impairment. Age and premorbid intelligence are however so related. Much of the impairment is recoverable with time but visuo-spatial abilities and abstract problem solving may remain impaired for a year or two and some aspects of long-term memorising may be permanently impaired. In general, older alcoholics show less capacity for recovery. The possibility that brain damage and cognitive impairment may antedate the alcoholism is considered as is the possibility that alcohol may be particularly damaging to the ageing brain. The relevance of pathophysiological disturbances and nutritional deficiency is also considered. Evidence is now accumulating that cognitive defect is an important predictor of outcome following treatment. In the management of states of impairment attention should be paid to remedying nutritional deficiencies and the general principles of rehabilitation should be borne in mind.
少数酗酒者会表现出明显的痴呆迹象,但大多数人在临床上看起来并无异常。尽管事实上,那些“看起来正常”的酗酒者中,近50%会被发现存在脑部结构损伤,但在常规智力测试中,他们的成绩仍会落在正常范围内。然而,更详细的心理测量测试会揭示出他们在非语言抽象能力、触觉表现以及带有感知成分的心理运动速度方面存在缺陷。饮酒量变量和脑部结构损伤程度均与损伤程度没有密切关联。然而,年龄和病前智力却与之相关。随着时间推移,大部分损伤是可以恢复的,但视觉空间能力和抽象问题解决能力可能会在一两年内持续受损,长期记忆的某些方面可能会永久性受损。一般来说,年长的酗酒者恢复能力较差。文中考虑了脑部损伤和认知障碍可能先于酗酒出现的可能性,以及酒精可能对衰老大脑造成特别损害的可能性。还考虑了病理生理紊乱和营养缺乏的相关性。现在越来越多的证据表明,认知缺陷是治疗后预后的重要预测指标。在处理损伤状态时,应注意纠正营养缺乏,并牢记康复的一般原则。