神经视网膜对大鼠晶状体纤维分化的影响。

Influence of neural retina on lens fibre differentiation in rats.

作者信息

McAvoy J W, Campbell M T, Walton J

出版信息

Aust N Z J Ophthalmol. 1985 May;13(2):103-11. doi: 10.1111/j.1442-9071.1985.tb00411.x.

DOI:10.1111/j.1442-9071.1985.tb00411.x

Abstract

Lens epithelial explants grown in retina-conditioned medium (RCM) undergo structural and molecular changes characteristic of fibre differentiation in the intact lens. We suggest that in vivo neural retina releases a fibre differentiation factor (FDF) that interacts with equatorial lens epithelial cells and stimulates them to undergo fibre cell differentiation. According to this model, interaction with neural retina is essential for normal lens formation in embryos and for normal lens growth throughout life. Preliminary work on purification of the factor indicates that FDF activity is associated with a high molecular weight complex of 500 kd. The active component of this complex appears to be an 80 kd molecule.

摘要

在视网膜条件培养基（RCM）中培养的晶状体上皮外植体经历了完整晶状体中纤维分化所特有的结构和分子变化。我们认为，在体内神经视网膜释放一种纤维分化因子（FDF），该因子与赤道部晶状体上皮细胞相互作用，并刺激它们进行纤维细胞分化。根据这个模型，与神经视网膜的相互作用对于胚胎中正常晶状体的形成以及一生中晶状体的正常生长至关重要。该因子纯化的初步工作表明，FDF活性与一个500kd的高分子量复合物相关。这个复合物的活性成分似乎是一个80kd的分子。