帕金森病相关富含亮氨酸重复激酶2（LRRK2）的结构生物学
Structural biology of Parkinson's disease-associated leucine-rich repeat kinase 2 (LRRK2).
作者信息
Leschziner Andres E
机构信息
Department of Cellular and Molecular Medicine, School of Medicine, University of California San Diego, La Jolla, California, USA; Department of Molecular Biology, School of Biological Sciences, University of California San Diego, La Jolla, California, USA; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, Maryland, USA.
出版信息
J Biol Chem. 2025 Jun 14;301(8):110376. doi: 10.1016/j.jbc.2025.110376.
Leucine-rich repeat kinase 2 (LRRK2) has gone, in a little over 2 decades, from a novel gene linked to cases of Parkinson's disease (PD) in one family to being the main actionable target for PD therapeutics, with several clinical trials targeting it currently underway. While much remains to be understood about LRRK2-including, chiefly, why its increased activity is linked to PD-much has also been learned. One of the areas where our knowledge has increased exponentially in a very short time is the structural biology of LRRK2. The goal of this review is to provide a survey of the current landscape of LRRK2 structural biology with an emphasis on the functional insights that structures have provided.
富含亮氨酸重复激酶2（LRRK2）在短短20多年的时间里，从一个与某一家族帕金森病（PD）病例相关的新基因，一跃成为PD治疗的主要可作用靶点，目前有多项针对它的临床试验正在进行。尽管关于LRRK2仍有许多有待了解的地方——主要包括为什么其活性增加与PD相关——但我们也已经了解到了很多。在很短的时间内，我们的知识呈指数级增长的领域之一就是LRRK2的结构生物学。这篇综述的目的是概述LRRK2结构生物学的当前概况，重点是结构所提供的功能见解。
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