Choi Yongsoo, Lee Miae, Kim BoMyoung, Kim Youngsil
Yong Animal CTMRI Medical Center, Changwon, Republic of Korea.
The Prime Animal Hospital, Busan, Republic of Korea.
Front Vet Sci. 2025 Jun 2;12:1590703. doi: 10.3389/fvets.2025.1590703. eCollection 2025.
Canine pancreatitis can lead to the digestion of nearby organs, and if untreated, it can develop into peritonitis. Widely used treatment as of now for acute pancreatitis (AP), however, largely depends on supportive treatment such as fluid therapy, antibiotics, and sufficient nutrient intake. Membrane-free stem cell extract (MF-STEM) is a protein mixture and other bioactive molecules derived from human adipose stem cells. MF-STEM is known for its anti-inflammatory and regenerative effects. This study was a vehicle-controlled clinical study. One hundred and forty-five canine pancreatitis patients with pancreatitis participated in this study with owners' consent. Following the owners' consent, 63 dogs received MF-STEM cell therapy with conventional therapy, and 82 dogs received conventional therapy. All participants had their cPL and CRP measured to evaluate their clinical progression. At the time of discharge, the survival rate in the MF-STEM cell therapy group survived (survival 92% and mortality 8%) more than the control group (survival 46% and mortality 54%). The authors suppose that MF-STEM cell increases survival of pancreatitis patients by modulating inflammatory cytokines. There were no side effects observed, such as allergic reactions and hypersensitivity reactions.
犬胰腺炎可导致邻近器官被消化，若不治疗，可发展为腹膜炎。然而，目前广泛应用于急性胰腺炎（AP）的治疗很大程度上依赖于支持性治疗，如液体疗法、抗生素和充足的营养摄入。无膜干细胞提取物（MF-STEM）是一种源自人脂肪干细胞的蛋白质混合物及其他生物活性分子。MF-STEM以其抗炎和再生作用而闻名。本研究是一项载体对照临床研究。145只患有胰腺炎的犬胰腺炎患者在获得主人同意后参与了本研究。在获得主人同意后，63只犬接受了MF-STEM细胞疗法联合传统疗法，82只犬接受了传统疗法。所有参与者均检测了其犬胰蛋白酶样免疫反应性（cPL）和C反应蛋白（CRP）以评估其临床进展。出院时，MF-STEM细胞疗法组的存活率（存活92%，死亡8%）高于对照组（存活46%，死亡54%）。作者推测MF-STEM细胞通过调节炎性细胞因子提高了胰腺炎患者的存活率。未观察到诸如过敏反应和超敏反应等副作用。
