Rimbert J N, Dumas F, Kellershohn C, Girot R, Brissot P
Biochimie. 1985 Jun;67(6):663-8. doi: 10.1016/s0300-9084(85)80209-1.
Absorption 57Fe Mössbauer spectra have been carried out directly on fresh or lyophylized tissues of liver with either normal iron depot or iron overload. Two types of overloading have been studied: primary iron overload due to an excessive intestinal iron absorption and secondary iron overload (hemosiderosis) produced in beta-thalassemia patients by hypertransfusional therapeutics. The Mössbauer spectra, at room temperature, 77 and 4.2 K, on normal liver samples, are typical for the ferritin-hemosiderin compounds. In the spectra, performed on hemosiderosis liver samples, there appears, in addition to ferritin and hemosiderin, a new iron molecular environment, typical of high spin ferric iron and characterized by a superparamagnetic behaviour which begins at high temperature (above 77 K). This new component does not show up in the primary iron overload cases and seems characteristic of the physiological process which induces the iron overload.
已直接对具有正常铁储存或铁过载的新鲜或冻干肝脏组织进行了吸收57Fe穆斯堡尔光谱分析。研究了两种类型的过载：由于肠道铁吸收过多导致的原发性铁过载，以及β地中海贫血患者通过高输血疗法产生的继发性铁过载（血色素沉着症）。在室温、77K和4.2K下对正常肝脏样本进行的穆斯堡尔光谱是铁蛋白-血铁黄素化合物的典型光谱。在对血色素沉着症肝脏样本进行的光谱中，除了铁蛋白和血铁黄素外，还出现了一种新的铁分子环境，这是高自旋铁离子的典型特征，其特征是在高温（高于77K）时开始出现超顺磁行为。这种新成分在原发性铁过载病例中未出现，似乎是诱导铁过载的生理过程的特征。
