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一位七旬患者的诊断困境:药物性肝损伤还是自身免疫性肝炎?

Diagnostic Dilemma in a Septuagenarian Patient: Drug-Induced Liver Injury (DILI) or Autoimmune Hepatitis?

作者信息

Nnonyelu Chibueze

机构信息

Internal Medicine, SSM Health St. Joseph Hospital, Saint Charles, USA.

出版信息

Cureus. 2025 May 16;17(5):e84253. doi: 10.7759/cureus.84253. eCollection 2025 May.

DOI:10.7759/cureus.84253
PMID:40525045
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12168721/
Abstract

Autoimmune hepatitis is an uncommon, long-term condition in which the immune system targets the liver, leading to inflammation. It can affect individuals of any age or background and often presents either without symptoms or with vague complaints such as tiredness, appetite loss, nausea, or weight reduction. While it can emerge at any point in life, it tends to occur more frequently during adolescence and again in later adulthood. This report describes the case of an elderly woman of Indian origin who was found to have elevated liver enzymes with no clear cause. Subsequent evaluations, including liver biopsy, confirmed autoimmune hepatitis. This case highlights the steps taken to reach a diagnosis and the complexities involved in choosing a suitable management plan.

摘要

自身免疫性肝炎是一种罕见的长期病症,免疫系统会攻击肝脏,导致炎症。它可影响任何年龄或背景的个体,通常无症状,或仅有诸如疲劳、食欲不振、恶心或体重减轻等模糊症状。虽然它可在生命中的任何时候出现,但在青春期和成年后期更易发生。本报告描述了一例印度裔老年女性的病例,该患者被发现肝功能酶升高但无明确病因。随后包括肝活检在内的评估确诊为自身免疫性肝炎。该病例突出了做出诊断所采取的步骤以及选择合适治疗方案所涉及的复杂性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3129/12168721/2024d30f390d/cureus-0017-00000084253-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3129/12168721/229a5d1f546a/cureus-0017-00000084253-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3129/12168721/2024d30f390d/cureus-0017-00000084253-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3129/12168721/229a5d1f546a/cureus-0017-00000084253-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3129/12168721/2024d30f390d/cureus-0017-00000084253-i02.jpg

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本文引用的文献

1
Diagnosis and management of autoimmune hepatitis.自身免疫性肝炎的诊断与管理
BMJ. 2023 Feb 6;380:e070201. doi: 10.1136/bmj-2022-070201.
2
Systematic review and meta-analysis on the incidence and prevalence of autoimmune hepatitis in Asian, European, and American population.系统评价和荟萃分析亚洲、欧洲和美洲人群自身免疫性肝炎的发病率和患病率。
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8
Centrilobular necrosis in autoimmune hepatitis: a histological feature associated with acute clinical presentation.自身免疫性肝炎中的小叶中心性坏死:一种与急性临床表现相关的组织学特征。
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International Autoimmune Hepatitis Group Report: review of criteria for diagnosis of autoimmune hepatitis.国际自身免疫性肝炎小组报告:自身免疫性肝炎诊断标准综述
J Hepatol. 1999 Nov;31(5):929-38. doi: 10.1016/s0168-8278(99)80297-9.
10
Chronic active hepatitis associated with antiliver/kidney microsome antibody type 1: a second type of "autoimmune" hepatitis.与1型抗肝肾微粒体抗体相关的慢性活动性肝炎:第二种“自身免疫性”肝炎。
Hepatology. 1987 Nov-Dec;7(6):1333-9. doi: 10.1002/hep.1840070626.