Mandim Andreia, Silva Ana Sofia, Moça Rita, Ribeiro Fani, Silva Rubina
Internal Medicine, Centro Hospitalar Póvoa de Varzim/Vila do Conde, Póvoa de Varzim, PRT.
Cureus. 2025 May 16;17(5):e84225. doi: 10.7759/cureus.84225. eCollection 2025 May.
Sarcomas are malignant tumors of mesenchymal origin that can occur throughout the body. Among these, undifferentiated round cell sarcomas are rare, aggressive tumors, often affecting young adults and presenting diagnostic challenges. We report the case of a 22-year-old female who presented with persistent chest pain and progressive respiratory distress. Despite extensive diagnostic efforts including imaging, thoracentesis, and exploratory laparoscopy, the diagnosis was delayed. Her condition deteriorated rapidly, culminating in sepsis, tumor lysis syndrome, and death. Post-mortem analysis confirmed a diagnosis of undifferentiated round cell sarcoma. This case illustrates the importance of considering rare malignancies in differential diagnoses and highlights the diagnostic and therapeutic challenges posed by these tumors.
肉瘤是间叶组织来源的恶性肿瘤,可发生于全身各处。其中,未分化圆形细胞肉瘤是罕见的侵袭性肿瘤,常影响年轻成年人,且在诊断上存在挑战。我们报告一例22岁女性病例,该患者出现持续性胸痛和进行性呼吸窘迫。尽管进行了包括影像学检查、胸腔穿刺和 exploratory laparoscopy(此处原文有误,可能是exploratory laparotomy,即剖腹探查术)等广泛的诊断工作,但诊断仍被延迟。她的病情迅速恶化,最终发展为脓毒症、肿瘤溶解综合征并死亡。尸检分析确诊为未分化圆形细胞肉瘤。该病例说明了在鉴别诊断中考虑罕见恶性肿瘤的重要性,并凸显了这些肿瘤所带来的诊断和治疗挑战。