Li Dian-Jeng, Wang Wen-Chun, Chou Frank Huang-Chih, Hsu Su-Ting, Hsieh Kuan-Ying, Lin Guei-Ging, Wu Pei-Jhen, Liu Chin-Lien, Wu Hui-Ching, Huang Joh-Jong
Department of Addiction Science, Kaohsiung Municipal Kai-Syuan Psychiatric Hospital, Kaohsiung, Taiwan.
Department of Nursing, Meiho University, Pingtung, Taiwan.
Psychol Res Behav Manag. 2025 Jun 10;18:1307-1318. doi: 10.2147/PRBM.S516814. eCollection 2025.
The rate of vaccination is lower in patients with schizophrenia than in the general population, and therefore, further investigation into the psychosocial impact of COVID-19 on these patients and their vaccine attitudes is warranted. In this study, we investigated factors influencing vaccine attitudes in patients with schizophrenia and explored the interactions among these factors.
Cross-sectional, self-report surveys were conducted among Taiwanese patients with schizophrenia to collect data on vaccine attitudes and associated variables. Our sample was drawn from the largest psychiatric specialty hospital in Taiwan. As of December 1, 2022, 88% of the Taiwanese population had received at least two doses of the COVID-19 vaccine. Factors influencing vaccine attitudes and potential moderators were investigated through correlation analyses, hierarchical regression, and Hayes' Process Macro.
This study included 457 patients. Our results revealed that social anxiety and social desirability were respectively positively and negatively correlated with vaccine attitudes. Positive thinking moderated the overall effect of social influence on vaccine attitudes. Low levels of positive thinking intensified the effect of social influence on vaccine hesitancy.
This study clarified the association of social influence with vaccine attitudes and the moderating effect of positive thinking on this association. Reputable medical centers can enhance patients' confidence in vaccination policies and foster positive thinking to increase vaccine acceptance among patients with schizophrenia.
精神分裂症患者的疫苗接种率低于普通人群，因此，有必要进一步调查新冠疫情对这些患者的心理社会影响及其疫苗态度。在本研究中，我们调查了影响精神分裂症患者疫苗态度的因素，并探讨了这些因素之间的相互作用。
对台湾地区的精神分裂症患者进行横断面自陈式调查，以收集有关疫苗态度及相关变量的数据。我们的样本来自台湾最大的精神科专科医院。截至2022年12月1日，88%的台湾人口已接种至少两剂新冠疫苗。通过相关分析、分层回归和海斯过程宏程序研究影响疫苗态度的因素和潜在调节因素。
本研究纳入了457名患者。我们的结果显示，社交焦虑与疫苗态度呈正相关，而社会期望与疫苗态度呈负相关。积极思维调节了社会影响对疫苗态度的总体效应。积极思维水平较低会增强社会影响对疫苗犹豫的作用。
本研究阐明了社会影响与疫苗态度之间的关联以及积极思维对这种关联的调节作用。声誉良好的医疗中心可以增强患者对疫苗接种政策的信心，并培养积极思维，以提高精神分裂症患者对疫苗的接受度。
