Lin Chien-Wen, Chang Yu-Ping, Yen Cheng-Fang
Department of Psychiatry, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan.
Department of Psychiatry, School of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Vaccines (Basel). 2023 Nov 29;11(12):1781. doi: 10.3390/vaccines11121781.
Individuals with schizophrenia are more likely to be infected with COVID-19 than are members of the general population. No prospective study has examined the associations of multi-dimensional factors with the motivation to receive vaccination against COVID-19. This follow-up study investigated the effects of individual (sociodemographic and illness characteristics, depression, and self-esteem), environmental (perceived social support), and individual-environmental interaction factors (self-stigma and loneliness) on the motivation to receive vaccination against COVID-19 and the number of COVID-19 vaccine doses received one year later among 300 individuals with schizophrenia. The associations of baseline factors with motivation to receive vaccination against COVID-19 and the number of vaccine doses received 1 year later were examined through linear regression analysis. The results indicated that greater loneliness ( < 0.01) and being married or cohabitating ( < 0.05) at baseline were significantly associated with lower motivation to receive vaccination against COVID-19 at follow-up. Disorganization ( < 0.05) at baseline was significantly associated with fewer COVID-19 vaccine doses at follow-up; greater motivation to receive vaccination was significantly associated with more COVID-19 vaccine doses at follow-up ( < 0.001). Health professionals should consider the identified predictors while developing intervention programs aimed at enhancing vaccination against COVID-19 in individuals with schizophrenia.
与普通人群相比，精神分裂症患者感染新冠病毒的可能性更高。尚无前瞻性研究考察多维因素与接种新冠疫苗意愿之间的关联。这项随访研究调查了个体因素（社会人口统计学和疾病特征、抑郁和自尊）、环境因素（感知到的社会支持）以及个体 - 环境交互因素（自我污名和孤独感）对300名精神分裂症患者接种新冠疫苗意愿以及一年后接种新冠疫苗剂量数的影响。通过线性回归分析检验了基线因素与接种新冠疫苗意愿以及一年后接种疫苗剂量数之间的关联。结果表明，基线时更高的孤独感（<0.01）以及已婚或同居（<0.05）与随访时较低的接种新冠疫苗意愿显著相关。基线时的紊乱症状（<0.05）与随访时较少的新冠疫苗接种剂量显著相关；更高的接种意愿与随访时更多的新冠疫苗接种剂量显著相关（<0.001）。在制定旨在提高精神分裂症患者新冠疫苗接种率的干预项目时，卫生专业人员应考虑已确定的预测因素。
