Liu Haoxin, Kehinde Ganiat, Pugh Analyce, Cocohoba Jennifer, Hodge Crystal K
University of North Texas System College of Pharmacy, Fort Worth, TX, USA.
University of California San Francisco, CA, USA.
J Prim Care Community Health. 2025 Jan-Dec;16:21501319251347869. doi: 10.1177/21501319251347869. Epub 2025 Jun 17.
More than 40 years after discovering HIV, the prognosis has transformed from an acute, fatal illness, to an average life expectancy approximating that of the general population. Correspondingly, new concerns regarding the management of older adults with HIV and multimorbidity are beginning to emerge. To support the HIV care continuum, people with HIV benefit from having a primary care medical home to address multimorbidity associated with age, genetic disposition, chronic HIV, and/or antiretroviral adverse effects. The interplay between HIV, antiretrovirals, and metabolic conditions is complex and is under study. It is imperative that primary care clinicians and medical team members are aware of how HIV and antiretrovirals can impact a person's comorbidities and corresponding mitigation strategies.
The goal of this commentary is to raise awareness of the metabolic consequences of modern antiretrovirals so that interdisciplinary teams caring for people with HIV can better coordinate the management of related conditions such as obesity, diabetes, and cardiovascular disease.
在发现艾滋病毒40多年后，其预后已从一种急性致命疾病转变为平均预期寿命接近普通人群的疾病。相应地，关于老年艾滋病毒感染者和多种疾病管理的新问题开始出现。为了支持艾滋病毒护理的连续性，艾滋病毒感染者受益于拥有一个初级保健医疗之家，以解决与年龄、遗传倾向、慢性艾滋病毒和/或抗逆转录病毒药物不良反应相关的多种疾病。艾滋病毒、抗逆转录病毒药物和代谢状况之间的相互作用很复杂，正在研究中。初级保健临床医生和医疗团队成员必须了解艾滋病毒和抗逆转录病毒药物如何影响一个人的合并症以及相应的缓解策略。
本评论的目的是提高对现代抗逆转录病毒药物代谢后果的认识，以便照顾艾滋病毒感染者的跨学科团队能够更好地协调肥胖、糖尿病和心血管疾病等相关疾病的管理。
