Nemes A, Acsády G, Fraefel W, Lichti H, Monos E, Oertli R, Somogyi E, Sótonyi P
Biomaterials. 1985 Sep;6(5):303-11. doi: 10.1016/0142-9612(85)90086-9.
The implantation and post-implantation behaviour of a Solcograft-P vascular prosthesis in the aortic, aorto-iliac, carotid and vena caval positions in dogs was studied up to 100 d post-surgery in order to assess the suitability of this vascular material for use in man. Solcograft-P is prepared from the carotid arteries of calves by crosslinking the collagen stroma using adipyl dichloride. During the postoperative follow-up period of 3 month, 100% of the aortal grafts, 80% of the aorto-iliac bypasses, 60% of the vena caval grafts and 35% of the carotid implants remained patent. The biochemical properties of the Solcograft-P are better than those of Solcograft, its predecessor. The intimal lining was consistently smooth and homogeneous in grafts of biological origin, and no aneurysm was observed. Infection and early thrombosis occured no more frequently than with other grafts. The new Solcograft-P, crosslinked via ester and amide groups, seems to represent a real improvement over Solcograft. Our results suggest that Solcograft-P should prove valuable in various cases of reconstructive vascular surgery of the lower limb, especially when the autologous vena saphena magna is not available, and its mechanical properties may well prove suitable for both arterial and venous replacement.
为评估Solcograft-P血管假体在人体使用的适用性，研究了其在犬主动脉、主-髂动脉、颈动脉和腔静脉部位植入及植入后的行为，直至术后100天。Solcograft-P由小牛颈动脉制备，通过用己二酰二氯交联胶原基质而成。在3个月的术后随访期内，100%的主动脉移植物、80%的主-髂动脉旁路移植物、60%的腔静脉移植物和35%的颈动脉植入物保持通畅。Solcograft-P的生化特性优于其前身Solcograft。生物源性移植物的内膜衬里始终光滑且均匀，未观察到动脉瘤。感染和早期血栓形成的发生率不比其他移植物高。通过酯基和酰胺基交联的新型Solcograft-P似乎比Solcograft有了真正的改进。我们的结果表明，Solcograft-P在下肢各种重建性血管手术中应具有价值，尤其是在无法获取大隐静脉自体移植物时，其机械性能很可能适用于动脉和静脉置换。
