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跨物种自主神经功能障碍的比较:当前知识与未来研究机遇

Comparison of Dysautonomia Across Species: Current Knowledge and Future Research Opportunities.

作者信息

Atkins Callum N, Hahn Caroline N, McGorum Bruce C

机构信息

Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Roslin, UK.

出版信息

J Vet Intern Med. 2025 Jul-Aug;39(4):e70140. doi: 10.1111/jvim.70140.

DOI:10.1111/jvim.70140
PMID:40525668
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12172005/
Abstract

Primary dysautonomia is a complex and often fatal autonomic nervous system disease. This literature review consolidates information on dysautonomia across species. Electronic databases (PubMed, Google Scholar and the Equine Grass Sickness Fund website) were systematically searched for veterinary and human medical literature on the topic. Nine hundred and fifty-six articles were identified, of which 158 were included in this review. The review covers the clinical presentation, etiology, diagnostic approaches, treatment strategies, and prognosis across different species. By integrating findings from multiple species, we aim to enhance understanding and inform future research and medical strategies regarding dysautonomia.

摘要

原发性自主神经功能障碍是一种复杂且往往致命的自主神经系统疾病。这篇文献综述整合了跨物种自主神经功能障碍的信息。我们系统地检索了电子数据库(PubMed、谷歌学术和马属动物青草搐搦症基金网站),以查找关于该主题的兽医和人类医学文献。共识别出956篇文章,其中158篇纳入了本综述。该综述涵盖了不同物种的临床表现、病因、诊断方法、治疗策略和预后。通过整合多个物种的研究结果,我们旨在增进对自主神经功能障碍的理解,并为未来关于自主神经功能障碍的研究和医学策略提供信息。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cba/12172005/5919e6dda93f/JVIM-39-e70140-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cba/12172005/598ea76a69b2/JVIM-39-e70140-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cba/12172005/b1b118a2b400/JVIM-39-e70140-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cba/12172005/b6b6dae6ecaa/JVIM-39-e70140-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cba/12172005/b578905a3700/JVIM-39-e70140-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cba/12172005/5919e6dda93f/JVIM-39-e70140-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cba/12172005/598ea76a69b2/JVIM-39-e70140-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cba/12172005/b1b118a2b400/JVIM-39-e70140-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cba/12172005/b6b6dae6ecaa/JVIM-39-e70140-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cba/12172005/b578905a3700/JVIM-39-e70140-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cba/12172005/5919e6dda93f/JVIM-39-e70140-g001.jpg

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本文引用的文献

1
Neurotoxic phospholipase A: A proposed cause of equine grass sickness and other animal dysautonomias (multiple system neuropathies).神经毒性磷脂酶A:马属动物青草搐搦症及其他动物自主神经功能障碍(多系统神经病变)的一种潜在病因。
Equine Vet J. 2025 Jan;57(1):11-18. doi: 10.1111/evj.14442.
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Lipofuscin accumulates in ganglionic neurons in chronic equine dysautonomia.脂褐素在慢性马运动机能障碍自主神经病变的神经节神经元中积累。
J Vet Diagn Invest. 2024 Nov;36(6):864-869. doi: 10.1177/10406387241265715. Epub 2024 Aug 7.
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A possible cause and therapy for equine grass sickness.
马属动物青草搐搦的一种可能病因及治疗方法。
Toxicon. 2024 Jul;245:107790. doi: 10.1016/j.toxicon.2024.107790. Epub 2024 May 29.
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Equine grass sickness is associated with major abnormalities in the ultrastructure of skeletal neuromuscular junctions.马属动物青草搐搦症与骨骼肌神经肌肉接头的超微结构的主要异常有关。
Equine Vet J. 2025 Jan;57(1):193-202. doi: 10.1111/evj.14063. Epub 2024 Feb 1.
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An overview on pure autonomic failure.纯自主神经衰竭概述。
Rev Neurol (Paris). 2024 Jan-Feb;180(1-2):94-100. doi: 10.1016/j.neurol.2023.11.003. Epub 2023 Dec 20.
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Cardiac F-dopamine positron emission tomography predicts the type of phenoconversion of pure autonomic failure.心脏 F-多巴胺正电子发射断层扫描预测纯自主神经衰竭的表型转化类型。
Clin Auton Res. 2023 Dec;33(6):737-747. doi: 10.1007/s10286-023-00987-1. Epub 2023 Oct 16.
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Synucleinopathies.突触核蛋白病。
Handb Clin Neurol. 2023;196:175-202. doi: 10.1016/B978-0-323-98817-9.00032-6.
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Diminished pupillary light reflexes, elevated third eyelids, and decreased tear production are commonly associated with canine dysautonomia.瞳孔对光反射减弱、第三眼睑抬高和泪液分泌减少通常与犬类自主神经功能紊乱有关。
J Am Vet Med Assoc. 2023 Jun 28;261(11):1-6. doi: 10.2460/javma.23.03.0134. Print 2023 Nov 1.
9
Dysautonomia in two littermate kittens.两只同窝小猫的自主神经功能障碍
JFMS Open Rep. 2023 Apr 28;9(1):20551169231164579. doi: 10.1177/20551169231164579. eCollection 2023 Jan-Jun.
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Clin Auton Res. 2021 Dec;31(6):677-684. doi: 10.1007/s10286-021-00829-y. Epub 2021 Oct 20.