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在一家城市性健康诊所实施多西环素暴露后预防措施后临床层面性传播感染负担的变化

Changes in clinic-level STI burden after doxycycline post-exposure prophylaxis implementation in an urban sexual health clinic.

作者信息

Jarolimova Jana, Bassett Ingrid V, Platt Laura, Germain Christine, Parker Robert A, Ard Kevin L

机构信息

Division of Infectious Disease, Massachusetts General Hospital, Boston, MA.

出版信息

Sex Transm Dis. 2025 Jun 17. doi: 10.1097/OLQ.0000000000002206.

DOI:10.1097/OLQ.0000000000002206
PMID:40525823
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12235504/
Abstract

In an urban sexual health clinic, a substantial portion of the clinic population initiated doxycycline post-exposure prophylaxis (doxyPEP) for bacterial STIs in the first 12 months, and implementation of doxyPEP was associated with a subsequent decrease in clinic-level chlamydia and syphilis positivity, but no change in overall gonorrhea positivity.

摘要

在一家城市性健康诊所,很大一部分就诊者在最初12个月内开始使用多西环素进行暴露后预防(doxyPEP)以预防细菌性性传播感染,实施doxyPEP与随后诊所层面衣原体和梅毒阳性率的下降相关,但总体淋病阳性率没有变化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/348f/12871400/8c5be42adfee/std-53-e5-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/348f/12871400/8c5be42adfee/std-53-e5-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/348f/12871400/8c5be42adfee/std-53-e5-g001.jpg

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本文引用的文献

1
Doxycycline Postexposure Prophylaxis and Bacterial Sexually Transmitted Infections Among Individuals Using HIV Preexposure Prophylaxis.在使用HIV暴露前预防药物的个体中,多西环素暴露后预防与细菌性性传播感染
JAMA Intern Med. 2025 Mar 1;185(3):273-281. doi: 10.1001/jamainternmed.2024.7186.
2
Doxycycline Postexposure Prophylaxis and Sexually Transmitted Infection Trends.多西环素暴露后预防与性传播感染趋势
JAMA Intern Med. 2025 Mar 1;185(3):266-272. doi: 10.1001/jamainternmed.2024.7178.
3
DoxyPEP: real-life effectiveness in a cohort of men who have sex with men in Milan, Italy.
多西环素暴露后预防(DoxyPEP):在意大利米兰男男性行为者队列中的实际效果
Lancet Infect Dis. 2025 Jan;25(1):e1-e3. doi: 10.1016/S1473-3099(24)00726-6. Epub 2024 Nov 19.
4
Use of Doxycycline and Other Antibiotics as Bacterial Sexually Transmitted Infection Prophylaxis in a US Sample of Primarily Gay and Bisexual Men.在美国主要为男同性恋和双性恋男性的样本中,使用多西环素和其他抗生素作为细菌性性传播感染预防措施。
Sex Transm Dis. 2024 Dec 1;51(12):763-771. doi: 10.1097/OLQ.0000000000002061. Epub 2024 Aug 8.
5
Trends in Sexually Transmitted Infections Associated With the Doxycycline Postexposure Prophylaxis Guidelines in San Francisco.旧金山多西环素暴露后预防指南相关的性传播感染趋势。
Sex Transm Dis. 2024 Nov 1;51(11):e46-e48. doi: 10.1097/OLQ.0000000000001996. Epub 2024 Jun 11.
6
CDC Clinical Guidelines on the Use of Doxycycline Postexposure Prophylaxis for Bacterial Sexually Transmitted Infection Prevention, United States, 2024.美国疾病预防控制中心 2024 年关于使用多西环素进行细菌性性传播感染预防的暴露后预防临床指南。
MMWR Recomm Rep. 2024 Jun 6;73(2):1-8. doi: 10.15585/mmwr.rr7302a1.
7
Postexposure Doxycycline to Prevent Bacterial Sexually Transmitted Infections.暴露后多西环素预防细菌性性传播感染。
N Engl J Med. 2023 Apr 6;388(14):1296-1306. doi: 10.1056/NEJMoa2211934.
8
Post-exposure prophylaxis with doxycycline to prevent sexually transmitted infections in men who have sex with men: an open-label randomised substudy of the ANRS IPERGAY trial.多西环素暴露后预防以预防男男性行为者中的性传播感染:ANRS IPERGAY 试验的开放性随机亚研究。
Lancet Infect Dis. 2018 Mar;18(3):308-317. doi: 10.1016/S1473-3099(17)30725-9. Epub 2017 Dec 8.