Recent advancements in double-expressor lymphoma: novel therapeutic approaches and prospects.

Double-expressor lymphoma (DEL) is a newly identified special subtype of diffuse large B-cell lymphoma (DLBCL), which is predominantly found in the activated B-cell-like (ABC) subtype of DLBCL. Characterized by concurrent overexpression of BCL2 and MYC, DEL is associated with poorer prognosis. Standard chemoimmunotherapy can achieve clinical cure in nearly 70% of DLBCL cases. DEL mainly presents with intermediate-to-high-risk international prognostic index scores, advanced stage at diagnosis, and may involve specific chromosomal rearrangements, mainly influencing older patients. These factors are interconnected and contribute to less favorable treatment outcomes. We review emerging drugs and clinical trial data potentially effective against DEL, formulating treatment recommendations based on evidence levels to provide a theoretical foundation for the clinical treatment of DEL.