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Relevance of Neutralizing Antibodies for the Pharmacokinetics of Pegunigalsidase Alfa in Patients with Fabry Disease.中和抗体对法布里病患者聚乙二醇化α-半乳糖苷酶药代动力学的影响
BioDrugs. 2025 Jan;39(1):153-165. doi: 10.1007/s40259-024-00690-1. Epub 2024 Nov 30.
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Optimizing Pharmacological and Immunological Properties of Therapeutic Proteins Through PEGylation: Investigating Key Parameters and Their Impact.通过聚乙二醇化优化治疗性蛋白质的药理学和免疫学性质:研究关键参数及其影响。
Drug Des Devel Ther. 2024 Nov 7;18:5041-5062. doi: 10.2147/DDDT.S481420. eCollection 2024.
3
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Bioeng Transl Med. 2023 Sep 22;9(1):e10600. doi: 10.1002/btm2.10600. eCollection 2024 Jan.
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Characterization of pre-existing anti-PEG and anti-AGAL antibodies towards PRX-102 in patients with Fabry disease.鉴定法布雷病患者体内针对 PRX-102 的抗聚乙二醇(PEG)和抗 A 型糖鞘脂酶(AGAL)抗体。
Front Immunol. 2023 Sep 22;14:1266082. doi: 10.3389/fimmu.2023.1266082. eCollection 2023.
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Comment on "Adverse Impacts of PEGylated Protein Therapeutics: A Targeted Literature Review".

作者信息

Goncalves Joao, Caliceti Paolo

机构信息

Faculty of Pharmacy, iMed-Research Institute for Medicines, University of Lisbon, Lisbon, Portugal.

Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy.

出版信息

BioDrugs. 2025 Jul;39(4):669-671. doi: 10.1007/s40259-025-00724-2. Epub 2025 Jun 17.

DOI:10.1007/s40259-025-00724-2
PMID:40526296
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12185576/
Abstract
摘要