Cai Ceng, Sitiwaerdi Yilidana, Zhang Wanyi, Xia Min, Mao Rui
Cancer Center, The First Affiliated Hospital of Xinjiang Medical University, No. 137 Liyushan Road, Urumqi, 830054, Xinjiang, China.
Dig Dis Sci. 2025 Jun 17. doi: 10.1007/s10620-025-09136-2.
Limited data are available on the relationship between expression of CDK4/CDK6 and prognosis in patients with adenocarcinoma of gastroesophageal junction (AEG).
A total of 135 patients diagnosed with AEG and treated with esophagogastrostomy were included in this study. Protein expression of CDK4 and CDK6 was assayed by immunohistochemistry staining and scored by two experienced pathologists. Differences in clinicopathologic parameters were analyzed between CDK4/CDK6-positive and -negative groups by Chi-square test and Fisher's exact test. The prognostic significance of CDK4/CDK6 in overall survival (OS) and progression-free survival (PFS) was assessed using the Kaplan-Meier method and log-rank test.
The positive rates of CDK4 and CDK6 in AEG tissues were significantly higher than in adjacent tissues. CDK4 positivity was correlated with poor tumor differentiation, and CDK6 positivity was related to perineural invasion and poor tumor differentiation. There were no significant differences between CDK4/CDK6 expression and OS or PFS of AEG patients.
CDK4/CDK6 may serve as prognostic factors for poor tumor differentiation, and CDK6 may also be a prognostic marker of perineural invasion for AEG patients.
关于胃食管交界腺癌（AEG）患者中CDK4/CDK6表达与预后之间的关系，现有数据有限。
本研究纳入了135例经诊断为AEG并接受食管胃吻合术治疗的患者。通过免疫组织化学染色检测CDK4和CDK6的蛋白表达，并由两名经验丰富的病理学家进行评分。采用卡方检验和Fisher精确检验分析CDK4/CDK6阳性组和阴性组之间临床病理参数的差异。使用Kaplan-Meier法和对数秩检验评估CDK4/CDK6在总生存期（OS）和无进展生存期（PFS）中的预后意义。
AEG组织中CDK4和CDK6的阳性率显著高于相邻组织。CDK4阳性与肿瘤低分化相关，CDK6阳性与神经周围浸润及肿瘤低分化有关。AEG患者的CDK4/CDK6表达与OS或PFS之间无显著差异。
CDK4/CDK6可能是肿瘤低分化的预后因素，CDK6也可能是AEG患者神经周围浸润的预后标志物。
