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苯丙胺精神病动物模型中额叶皮质多巴胺利用的持久增强。

Enduring enhancement in frontal cortex dopamine utilization in an animal model of amphetamine psychosis.

作者信息

Robinson T E, Becker J B, Moore C J, Castañeda E, Mittleman G

出版信息

Brain Res. 1985 Sep 23;343(2):374-7. doi: 10.1016/0006-8993(85)90760-7.

DOI:10.1016/0006-8993(85)90760-7
PMID:4052758
Abstract

It is reported that in rats the repeated intermittent administration of amphetamine produces a long-lasting enhancement in medial frontal cortex dopamine utilization. This change in mesocortical dopamine activity may be involved in the behavioral sensitization produced by psychomotor stimulant drugs, and some of the cognitive abnormalities (e.g. amphetamine psychosis) associated with stimulant drug abuse in humans.

摘要

据报道，在大鼠中，反复间歇性给予苯丙胺会使内侧前额叶皮质的多巴胺利用产生持久增强。中脑皮质多巴胺活性的这种变化可能与精神运动性兴奋药物引起的行为敏化有关，也与人类滥用兴奋药物相关的一些认知异常（如苯丙胺精神病）有关。

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