要如何证明慢性感染是阿尔茨海默病的致病因素呢？
What would it take to prove that a chronic infection is a causal agent in Alzheimer's disease?
作者信息
Brutkiewicz Randy R, Cao Wei, Morgan David, Reis Roberta Souza Dos, Suryadevara Vidyani, Willette Auriel A, Willette Sara A, Wyatt-Johnson Season K, Duggan Michael R
机构信息
Department of Microbiology and Immunology, Stark Neuroscience Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA.
Department of Anesthesiology, Critical Care and Pain Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
出版信息
Trends Neurosci. 2025 Aug;48(8):608-623. doi: 10.1016/j.tins.2025.05.009. Epub 2025 Jun 16.
Accumulating evidence over several years suggests that microbial infections (e.g., bacteria, viruses, fungi) may play a role in the etiology of Alzheimer's disease (AD). In this review, we discuss the reported associations between a variety of microbes and the development of AD, as well as potential causal relationships between infections and AD risk. Having evaluated the current state of knowledge, we make specific recommendations for what it would take to present definitive evidence that chronic infections play a causal role in AD pathogenesis.
数年来不断积累的证据表明，微生物感染（如细菌、病毒、真菌）可能在阿尔茨海默病（AD）的病因学中起作用。在本综述中，我们讨论了各种微生物与AD发生之间已报道的关联，以及感染与AD风险之间潜在的因果关系。在评估了当前的知识状况后，我们就如何提供确凿证据证明慢性感染在AD发病机制中起因果作用提出了具体建议。
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