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Clinical outcomes of offspring and matched unrelated donor transplants in relapsed or refractory severe aplastic anemia patients aged 40-50: a retrospective analysis from the CBMTR over the past decade.

作者信息

Zhao Xin, Zhang Yu-Ping, Ye Bao-Dong, Lu Pei-Hua, Chen Jie-Ping, Zhang Jian-Ping, Li Xin, Su Guo-Hong, Zhang Yan-Ming, Jiang Er-Lie, Zhou Fang, Liu Dai-Hong, Sun Zi-Min, Qin Wei-Wei, Yi Hai, Ran Xue-Hong, Xu Ya-Jing, Zhang Xi, Huang Xiao-Jun, Wang Shun-Qing, Xu Lan-Ping

机构信息

Peking University Institute of Hematology, Peking University People's Hospital, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China.

Department of Hematology, Guangzhou First People's Hospital, Institute of Blood Transfusion and Hematology Guangzhou Medical University, Guangzhou, China.

出版信息

Bone Marrow Transplant. 2025 Jun 17. doi: 10.1038/s41409-025-02617-y.

DOI:10.1038/s41409-025-02617-y
PMID:40527980
Abstract
摘要

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1
Clinical outcomes of offspring and matched unrelated donor transplants in relapsed or refractory severe aplastic anemia patients aged 40-50: a retrospective analysis from the CBMTR over the past decade.40-50岁复发或难治性重型再生障碍性贫血患者子代及匹配无关供者移植的临床结局：中国造血干细胞移植登记系统过去十年的回顾性分析
Bone Marrow Transplant. 2025 Jun 17. doi: 10.1038/s41409-025-02617-y.
2
First-line allogeneic hematopoietic stem cell transplantation of HLA-matched sibling donors compared with first-line ciclosporin and/or antithymocyte or antilymphocyte globulin for acquired severe aplastic anemia.与一线使用环孢素和/或抗胸腺细胞或抗淋巴细胞球蛋白治疗获得性重型再生障碍性贫血相比，HLA匹配的同胞供者进行一线异基因造血干细胞移植的情况。
Cochrane Database Syst Rev. 2013 Jul 23;2013(7):CD006407. doi: 10.1002/14651858.CD006407.pub2.
3
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Haematologica. 2009 Dec;94(12):1732-42. doi: 10.3324/haematol.2009.007583. Epub 2009 Jul 31.
4
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本文引用的文献

1
Comparable survival outcomes in HLA-Matched and haploidentical hematopoietic stem cell transplantation for severe aplastic anemia patients aged 40-50: A CBMTR Registry-based propensity score matching analysis over the last decade.
Cancer Lett. 2025 Jul 1;621:217594. doi: 10.1016/j.canlet.2025.217594. Epub 2025 Mar 27.
2
The outcome of allogeneic hematopoietic stem cell transplantation among elderly patients with severe aplastic anemia and a predictive model from the Chinese Blood and Marrow Transplant Registry group.老年重型再生障碍性贫血患者异基因造血干细胞移植的结局及中国血液和骨髓移植登记组的预测模型
Haematologica. 2024 Jun 1;109(6):2000-2004. doi: 10.3324/haematol.2023.284581.
3
Graft--host disease and relapse/rejection-free survival after allogeneic transplantation for idiopathic severe aplastic anemia: a comprehensive analysis from the SAAWP of the EBMT.同种异体移植治疗特发性重型再生障碍性贫血后移植物抗宿主病和无复发/排斥反应生存：来自 EBMT 的 SAAWP 的综合分析。
Haematologica. 2023 Sep 1;108(9):2305-2315. doi: 10.3324/haematol.2022.281876.
4
Haploidentical bone marrow transplantation in patients with relapsed or refractory severe aplastic anaemia in the USA (BMT CTN 1502): a multicentre, single-arm, phase 2 trial.美国复发性或难治性重型再生障碍性贫血患者的单倍体相合骨髓移植（BMT CTN 1502）：一项多中心、单臂、2 期临床试验。
Lancet Haematol. 2022 Sep;9(9):e660-e669. doi: 10.1016/S2352-3026(22)00206-X. Epub 2022 Jul 27.
5
Optimizing outcomes for haploidentical hematopoietic stem cell transplantation in severe aplastic anemia with intensive GVHD prophylaxis: a review of current findings.优化强化移植物抗宿主病预防方案下重型再生障碍性贫血患者单倍体造血干细胞移植的结局：对现有研究结果的综述。
Expert Rev Hematol. 2021 May;14(5):449-455. doi: 10.1080/17474086.2021.1923475. Epub 2021 May 10.
6
Improved survival after offspring donor transplant compared with older aged-matched siblings for older leukaemia patients.对于老年白血病患者，与年龄匹配的年长同胞供体相比，后代供体移植后的生存率得到了提高。
Br J Haematol. 2020 Apr;189(1):153-161. doi: 10.1111/bjh.16303. Epub 2019 Nov 7.
7
How I treat acquired aplastic anemia.我如何治疗获得性再生障碍性贫血。
Blood. 2017 Mar 16;129(11):1428-1436. doi: 10.1182/blood-2016-08-693481. Epub 2017 Jan 17.
8
Haplo-identical transplantation for acquired severe aplastic anaemia in a multicentre prospective study.单倍型相合移植治疗获得性重型再生障碍性贫血的多中心前瞻性研究
Br J Haematol. 2016 Oct;175(2):265-274. doi: 10.1111/bjh.14225. Epub 2016 Jun 28.
9
Donor characteristics as risk factors in recipients after transplantation of bone marrow from unrelated donors: the effect of donor age.无关供体骨髓移植后受体中作为风险因素的供体特征：供体年龄的影响
Blood. 2001 Oct 1;98(7):2043-51. doi: 10.1182/blood.v98.7.2043.