Godin D, Campeau N, Nadeau R, Cardinal R, de Champlain J
Can J Physiol Pharmacol. 1985 Sep;63(9):1088-95. doi: 10.1139/y85-179.
In anesthetized dogs, 60-min occlusions of either the proximal (n = 14), distal (n = 8) left circumflex (LCX), or left anterior descending (LAD, n = 10) arteries were followed by reperfusion. Coronary sinus and aortic norepinephrine and epinephrine plasma concentrations were measured. The ventricular arrhythmias were ventricular premature depolarizations (VPDs), unsustained ventricular tachycardia (VT) (greater than or equal to 3 and less than 20 VPDs), sustained VT (greater than or equal to 20 VPDs), and ventricular fibrillation (VF). A gradual twofold increase (p less than 0.05) in myocardial norepinephrine overflow followed occlusion in all three groups. The increases in the amounts of norepinephrine released in the coronary sinus blood during reperfusion were significant and proportional to the size of the occluded area: proximal LCX, from 0.236 +/- 0.038 to 1.528 +/- 0.490 ng/mL of plasma (p less than 0.001); LAD, from 0.180 +/- 0.027 to 0.795 +/- 0.286 ng/mL (p less than 0.05); distal LCX, from 0.215 +/- 0.039 to 0.404 +/- 0.110 ng/mL (p less than 0.05). Aortic epinephrine concentrations were significantly increased only by LAD occlusion; at 15 min, the value had increased to 0.187 +/- 0.053 ng/mL from an initial value of 0.069 +/- 0.029 ng/mL (p less than 0.001). Two phases of ventricular arrhythmias followed both occlusion and reperfusion. Phase 1 postocclusion was characterized by VPDs and phase 2 by VPDs and unsustained VT. Sustained VT was seen only in phase 1 postreperfusion, whereas unsustained VT was seen in phase 2. VF was seen in 50, 35, and 25% of the dogs with proximal LCX, LAD, and distal LCX occlusion and reperfusion.(ABSTRACT TRUNCATED AT 250 WORDS)
在麻醉犬中，对左回旋支（LCX）近端（n = 14）、远端（n = 8）或左前降支（LAD，n = 10）动脉进行60分钟的闭塞，随后再灌注。测量冠状窦和主动脉中去甲肾上腺素和肾上腺素的血浆浓度。室性心律失常包括室性早搏（VPD）、非持续性室性心动过速（VT）（≥3且＜20个VPD）、持续性VT（≥20个VPD）和心室颤动（VF）。三组在闭塞后心肌去甲肾上腺素溢出均逐渐增加两倍（p＜0.05）。再灌注期间冠状窦血中去甲肾上腺素释放量的增加显著且与闭塞面积大小成正比：近端LCX，从0.236±0.038 ng/mL血浆增至1.528±0.490 ng/mL（p＜0.001）；LAD，从0.180±0.027 ng/mL增至0.795±0.286 ng/mL（p＜0.05）；远端LCX，从0.215±0.039 ng/mL增至0.404±0.110 ng/mL（p＜0.05）。仅LAD闭塞使主动脉肾上腺素浓度显著升高；在15分钟时，该值从初始值0.069±0.029 ng/mL增至0.187±0.053 ng/mL（p＜0.001）。闭塞和再灌注后均出现两个室性心律失常阶段。闭塞后第1阶段以VPD为特征，第2阶段以VPD和非持续性VT为特征。持续性VT仅在再灌注后第1阶段出现，而非持续性VT在第2阶段出现。在近端LCX、LAD和远端LCX闭塞并再灌注的犬中，VF分别出现在50%、35%和25%的犬中。（摘要截断于250字）
