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一名男性患者以酷似脑膜瘤的孤立性脑转移作为同时性肺和乳腺肉瘤样癌的初始表现:一种罕见病例并文献复习

Solitary brain metastasis mimicking meningioma as the initial presentation of concurrent pulmonary and breast sarcomatoid carcinoma in a male patient: A rare entity with literature review.

作者信息

Borni Mehdi, Kolsi Fatma, Ben Fradj Seif, Dammak Imen, Souissi Basma, Saguem Ines, Boudawara Med Zaher

机构信息

Department of Neurosurgery, UHC Habib Bourguiba, Sfax, Tunisia.

Department of Radiology, UHC Habib Bourguiba, Sfax, Tunisia.

出版信息

Radiol Case Rep. 2025 Jun 7;20(9):4245-4251. doi: 10.1016/j.radcr.2025.05.016. eCollection 2025 Sep.

Abstract

Sarcomatoid carcinomas are very rare mixed malignancies, belonging to the subtype of non-small-cell-lung cancer composed of epithelial and mesenchymal tissues. These tumors represent 0.1%-0.3% of all lung cancers. Involvement of the central nervous system remains rare and only few cases were reported in the literature. There are no standards for the treatment of this cancer. It is a tumor of poor prognosis, known by its recurrences both local and distant with a relatively high mortality rate. The authors present a novel and rare case of pulmonary sarcomatoid carcinoma, identified through a comprehensive review of the current literature. This case involves a 55-year-old male patient who initially presented with progressive signs and symptoms of raised intracranial pressure, without any respiratory complaints. Further investigation revealed a solitary left frontal brain metastasis and an incidentally discovered breast metastasis.

摘要

肉瘤样癌是非常罕见的混合性恶性肿瘤,属于由上皮组织和间叶组织构成的非小细胞肺癌亚型。这些肿瘤占所有肺癌的0.1%-0.3%。中枢神经系统受累仍然罕见,文献中仅报道了少数病例。这种癌症没有标准的治疗方法。它是一种预后较差的肿瘤,以局部和远处复发以及相对较高的死亡率而闻名。作者通过对当前文献的全面综述,呈现了一例新颖且罕见的肺肉瘤样癌病例。该病例涉及一名55岁男性患者,最初表现为进行性颅内压升高的体征和症状,无任何呼吸道症状。进一步检查发现左额叶孤立性脑转移和偶然发现的乳腺转移。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c82c/12173651/3c66a44bb29b/gr1.jpg

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