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一名男性患者以酷似脑膜瘤的孤立性脑转移作为同时性肺和乳腺肉瘤样癌的初始表现:一种罕见病例并文献复习

Solitary brain metastasis mimicking meningioma as the initial presentation of concurrent pulmonary and breast sarcomatoid carcinoma in a male patient: A rare entity with literature review.

作者信息

Borni Mehdi, Kolsi Fatma, Ben Fradj Seif, Dammak Imen, Souissi Basma, Saguem Ines, Boudawara Med Zaher

机构信息

Department of Neurosurgery, UHC Habib Bourguiba, Sfax, Tunisia.

Department of Radiology, UHC Habib Bourguiba, Sfax, Tunisia.

出版信息

Radiol Case Rep. 2025 Jun 7;20(9):4245-4251. doi: 10.1016/j.radcr.2025.05.016. eCollection 2025 Sep.

DOI:10.1016/j.radcr.2025.05.016
PMID:40528903
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12173651/
Abstract

Sarcomatoid carcinomas are very rare mixed malignancies, belonging to the subtype of non-small-cell-lung cancer composed of epithelial and mesenchymal tissues. These tumors represent 0.1%-0.3% of all lung cancers. Involvement of the central nervous system remains rare and only few cases were reported in the literature. There are no standards for the treatment of this cancer. It is a tumor of poor prognosis, known by its recurrences both local and distant with a relatively high mortality rate. The authors present a novel and rare case of pulmonary sarcomatoid carcinoma, identified through a comprehensive review of the current literature. This case involves a 55-year-old male patient who initially presented with progressive signs and symptoms of raised intracranial pressure, without any respiratory complaints. Further investigation revealed a solitary left frontal brain metastasis and an incidentally discovered breast metastasis.

摘要

肉瘤样癌是非常罕见的混合性恶性肿瘤,属于由上皮组织和间叶组织构成的非小细胞肺癌亚型。这些肿瘤占所有肺癌的0.1%-0.3%。中枢神经系统受累仍然罕见,文献中仅报道了少数病例。这种癌症没有标准的治疗方法。它是一种预后较差的肿瘤,以局部和远处复发以及相对较高的死亡率而闻名。作者通过对当前文献的全面综述,呈现了一例新颖且罕见的肺肉瘤样癌病例。该病例涉及一名55岁男性患者,最初表现为进行性颅内压升高的体征和症状,无任何呼吸道症状。进一步检查发现左额叶孤立性脑转移和偶然发现的乳腺转移。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c82c/12173651/efff953f864e/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c82c/12173651/3c66a44bb29b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c82c/12173651/0954943b8b71/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c82c/12173651/2bb831521a53/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c82c/12173651/8f1a39dc614c/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c82c/12173651/1b35fcf072f2/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c82c/12173651/efff953f864e/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c82c/12173651/3c66a44bb29b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c82c/12173651/0954943b8b71/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c82c/12173651/2bb831521a53/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c82c/12173651/8f1a39dc614c/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c82c/12173651/1b35fcf072f2/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c82c/12173651/efff953f864e/gr6.jpg

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本文引用的文献

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Introduction to The 2015 World Health Organization Classification of Tumors of the Lung, Pleura, Thymus, and Heart.《2015年世界卫生组织肺、胸膜、胸腺和心脏肿瘤分类》简介
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A case-control analysis of survival outcomes in sinonasal carcinosarcoma.鼻窦癌肉瘤生存结局的病例对照分析。
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Management of spindle cell carcinoma of the maxillary sinus: a case report and literature review.
上颌窦梭形细胞癌的治疗:一例报告及文献综述
Am J Case Rep. 2014 Oct 24;15:454-8. doi: 10.12659/AJCR.891007.
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Sarcomatoid carcinoma involving the nasal cavity and paranasal sinus: a rare and highly progressive tumor.累及鼻腔和鼻窦的肉瘤样癌:一种罕见且高度侵袭性的肿瘤。
Int J Clin Exp Pathol. 2014 Jun 15;7(7):4489-92. eCollection 2014.
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Report of a rare case of carcinosarcoma of the maxillary sinus with sternal metastasis.上颌窦癌肉瘤伴胸骨转移罕见病例报告。
Ear Nose Throat J. 2014 Jun;93(6):E1-4.
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Sarcomatoid carcinoma of the lung with brain metastases.伴有脑转移的肺肉瘤样癌
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Sarcomatoid carcinoma of the lung: histologic criteria and common lesions in the differential diagnosis.肺肉瘤样癌:组织学标准和鉴别诊断中的常见病变。
Arch Pathol Lab Med. 2010 Jan;134(1):49-54. doi: 10.5858/2008-0547-RAR.1.
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Clinical characteristics of pleomorphic carcinoma of the lung.肺多形性癌的临床特征。
Lung Cancer. 2010 May;68(2):204-10. doi: 10.1016/j.lungcan.2009.06.002. Epub 2009 Jul 3.
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Pleomorphic carcinoma of the lung: clinicopathologic characteristics of 70 cases.肺多形性癌:70例临床病理特征
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